Gold- and Silver-Catalyzed 7-endo-dig Cyclizations for the Synthesis of Oxazepines

Anatoly A. Peshkov, Anton A. Nechaev, Olga P. Pereshivko, Jan L. Goeman, Johan Van Der Eycken, Vsevolod A. Peshkov, Erik V. Van Der Eycken

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A comprehensive study on gold- and silver-catalyzed cycloisomerizations of hydroxypropargylamides into oxazepines is described. Three different types of hydroxypropargylamide substrates derived from either amide coupling or Ugi reactions have been validated resulting in establishment of selective and general access to a medium-ring oxazepine core. A comprehensive study on gold- and silver-catalyzed cycloisomerizations of hydroxypropargylamides into oxazepines is described.

Original languageEnglish
Pages (from-to)4190-4197
Number of pages8
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number19
DOIs
Publication statusPublished - Jul 1 2015
Externally publishedYes

Fingerprint

Oxazepines
Cyclization
Silver
Gold
silver
gold
synthesis
amides
Amides
rings
Substrates

Keywords

  • Cyclization
  • Medium-ring compounds
  • Multicomponent reactions
  • Nitrogen heterocycles
  • Synthetic methods

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Peshkov, A. A., Nechaev, A. A., Pereshivko, O. P., Goeman, J. L., Van Der Eycken, J., Peshkov, V. A., & Van Der Eycken, E. V. (2015). Gold- and Silver-Catalyzed 7-endo-dig Cyclizations for the Synthesis of Oxazepines. European Journal of Organic Chemistry, 2015(19), 4190-4197. https://doi.org/10.1002/ejoc.201500357

Gold- and Silver-Catalyzed 7-endo-dig Cyclizations for the Synthesis of Oxazepines. / Peshkov, Anatoly A.; Nechaev, Anton A.; Pereshivko, Olga P.; Goeman, Jan L.; Van Der Eycken, Johan; Peshkov, Vsevolod A.; Van Der Eycken, Erik V.

In: European Journal of Organic Chemistry, Vol. 2015, No. 19, 01.07.2015, p. 4190-4197.

Research output: Contribution to journalArticle

Peshkov, AA, Nechaev, AA, Pereshivko, OP, Goeman, JL, Van Der Eycken, J, Peshkov, VA & Van Der Eycken, EV 2015, 'Gold- and Silver-Catalyzed 7-endo-dig Cyclizations for the Synthesis of Oxazepines', European Journal of Organic Chemistry, vol. 2015, no. 19, pp. 4190-4197. https://doi.org/10.1002/ejoc.201500357
Peshkov, Anatoly A. ; Nechaev, Anton A. ; Pereshivko, Olga P. ; Goeman, Jan L. ; Van Der Eycken, Johan ; Peshkov, Vsevolod A. ; Van Der Eycken, Erik V. / Gold- and Silver-Catalyzed 7-endo-dig Cyclizations for the Synthesis of Oxazepines. In: European Journal of Organic Chemistry. 2015 ; Vol. 2015, No. 19. pp. 4190-4197.
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