Gold-Catalyzed Post-Ugi Cascade Transformation for the Synthesis of 2-Pyridones

Xiaochen Du, Jiafeng Yu, Jing Gong, Manzoor Zaman, Olga P. Pereshivko, Vsevolod A. Peshkov

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A gold-catalyzed post-Ugi cascade transformation for the synthesis of 2-pyridones is described. The process involves furan–alkyne cyclization followed by furan ring-opening and cleavage of the isocyanide-originated fragment. The initially formed cis double bond can isomerize into a more stable trans double bond upon prolonged exposure to a strong Brønsted acid. Thus, the overall strategy provides a viable access towards two types of 2-pyridones.

Original languageEnglish
Pages (from-to)2502-2507
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number14
Publication statusPublished - Apr 16 2019


  • 2-Pyridones
  • Cascade transformations
  • Gold catalysis
  • Multicomponent reactions
  • Ugi reaction

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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