Gold nanoparticles-mediated laser ablation therapy monitored with optical fibers sensing network in real time

Zhannat Ashikbaeva, Arman Aitkulov, Madina Jelbuldina, Aizhan Issatayeva, Aidana Beisenova, Carlo Molardi, Paola Saccomandi, Wilfried Blanc, Vasileios Inglezakis, Daniele Tosi

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Nowadays, the application of nanoparticles for biomedical purposes is a promising and innovative tool for the thermal therapy of tumors. Gold nanoparticles are distinguished by their tunable optical properties, biocompatibility, and ease of synthesis. The ability of gold nanoparticles to absorb light at near-infrared region (NIR) to generate localized heat allows temperature elevation and optimizing the temperature distribution during short-time laser ablation. The synthesized 20-nm gold nanoparticles injected on the surface of the tissue demonstrated rapid and diffused heat increase enlarging the shape of the treated region compared to the pristine tissue. Another advantage of this work is the proposed optical fiber distributed sensing network over the laser ablation assisted with nanomaterials. The sensing system uses single-mode enhanced-backscattering optical fibers doped with MgO nanoparticles; it achieves narrow spatial resolution, which demonstrates accurate temperature distribution monitoring in real time, in 2-dimensions over 5.4 cm2 area at 16 sensing points per fiber. The obtained sensing data allowed to calculate the treated area and provided the information when the ablation process should be terminated in order to avoid the vaporization of tissue after reaching the temperature of 100 °C. The calculated damage threshold (>60 °C) areas are 2.57 cm2 with gold nanoparticles, compared to 1.33 mm2 pristine. The results of this work provide the solution to two issues existing during laser ablation that are possible damage of undesired area and the ability to precisely monitor the temperature in real time that is compatible to MRI.

Original languageEnglish
Title of host publicationMechanisms and Techniques in Photodynamic Therapy and Photobiomodulation
EditorsDavid H. Kessel, Praveen Arany, Tayyaba Hasan, James D. Carroll, Ann Liebert
ISBN (Electronic)9781510640917
Publication statusPublished - 2021
EventMechanisms and Techniques in Photodynamic Therapy and Photobiomodulation 2021 - Virtual, Online, United States
Duration: Mar 6 2021Mar 11 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMechanisms and Techniques in Photodynamic Therapy and Photobiomodulation 2021
Country/TerritoryUnited States
CityVirtual, Online


  • Distributed sensing
  • Gold nanoparticles
  • MgO nanoparticle doped optical fibers
  • Optical fibers

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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