@inproceedings{1b8185322573458ba3207dd5fa234ab4,
title = "Gold nanoparticles-mediated laser ablation therapy monitored with optical fibers sensing network in real time",
abstract = "Nowadays, the application of nanoparticles for biomedical purposes is a promising and innovative tool for the thermal therapy of tumors. Gold nanoparticles are distinguished by their tunable optical properties, biocompatibility, and ease of synthesis. The ability of gold nanoparticles to absorb light at near-infrared region (NIR) to generate localized heat allows temperature elevation and optimizing the temperature distribution during short-time laser ablation. The synthesized 20-nm gold nanoparticles injected on the surface of the tissue demonstrated rapid and diffused heat increase enlarging the shape of the treated region compared to the pristine tissue. Another advantage of this work is the proposed optical fiber distributed sensing network over the laser ablation assisted with nanomaterials. The sensing system uses single-mode enhanced-backscattering optical fibers doped with MgO nanoparticles; it achieves narrow spatial resolution, which demonstrates accurate temperature distribution monitoring in real time, in 2-dimensions over 5.4 cm2 area at 16 sensing points per fiber. The obtained sensing data allowed to calculate the treated area and provided the information when the ablation process should be terminated in order to avoid the vaporization of tissue after reaching the temperature of 100 °C. The calculated damage threshold (>60 °C) areas are 2.57 cm2 with gold nanoparticles, compared to 1.33 mm2 pristine. The results of this work provide the solution to two issues existing during laser ablation that are possible damage of undesired area and the ability to precisely monitor the temperature in real time that is compatible to MRI.",
keywords = "Distributed sensing, Gold nanoparticles, MgO nanoparticle doped optical fibers, Optical fibers",
author = "Zhannat Ashikbaeva and Arman Aitkulov and Madina Jelbuldina and Aizhan Issatayeva and Aidana Beisenova and Carlo Molardi and Paola Saccomandi and Wilfried Blanc and Vasileios Inglezakis and Daniele Tosi",
note = "Funding Information: The research was funded by Nazarbayev University, under Grants SMARTER (Code: 091019CRP2117) and EPICGuide (Code: 240919FD3908). The partial financial support was done by ANR Projects Nice-DREAM (ANR-14-CE07-0016-03), NanoSlim (ANR-17-CE08-0002), and by LASEROPTIMAL@POLIMI Project (Rif. 2017-2075). The authors acknowledge Damir Balmassov for the support in drawing Figure 1. Publisher Copyright: {\textcopyright} 2021 SPIE; Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation 2021 ; Conference date: 06-03-2021 Through 11-03-2021",
year = "2021",
doi = "10.1117/12.2582662",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Kessel, {David H.} and Praveen Arany and Tayyaba Hasan and Carroll, {James D.} and Ann Liebert",
booktitle = "Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation",
address = "United States",
}