Gorilla major histocompatibility complex-DRB pseudogene orthologous to HLA-DRBVIII

Dagmar Klein, Vladimir Vincek, Masanori Kasahara, Christian Schönbach, Colm O'hUigin, Jan Klein

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for β chains of the αβ heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA DRw53 determinants, respectively; the DRBVII and DRBVIII are pseudogenes. We found and sequenced a gene closely related to HLA-DRBVIII in the genome of the lowland gorilla "Sylvia". We designate this gene Gogo-DRB8. The close relationship between the two genes is indicated by the overall sequence similarity, the absence of recognizable exons 1 and 2 in both genes, the presence if two Alu repeats at corresponding positions, and high sequence similarity between corresponding repeats. The comparison with an outgroup (tamarin) gene and the functional counterparts of the DRB8 gene indicate that DRB8 emerged between 18 and 26 million years ago and became inactivated at the same time as or shortly after its creation. Hence DRB8 has probably existed as a pseudogene since the divergence of apes from Old World monkeys more than 20 million years ago. Human Immunology 32, 211-220 (1991).

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalHuman Immunology
Volume32
Issue number3
DOIs
Publication statusPublished - 1991
Externally publishedYes

Fingerprint

Dichlororibofuranosylbenzimidazole
Gorilla gorilla
Pseudogenes
Major Histocompatibility Complex
Genes
HLA-DR4 Antigen
Cercopithecidae
Hominidae
Allergy and Immunology
Haplotypes
Exons
Chromosomes
Genome

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Gorilla major histocompatibility complex-DRB pseudogene orthologous to HLA-DRBVIII. / Klein, Dagmar; Vincek, Vladimir; Kasahara, Masanori; Schönbach, Christian; O'hUigin, Colm; Klein, Jan.

In: Human Immunology, Vol. 32, No. 3, 1991, p. 211-220.

Research output: Contribution to journalArticle

Klein, Dagmar ; Vincek, Vladimir ; Kasahara, Masanori ; Schönbach, Christian ; O'hUigin, Colm ; Klein, Jan. / Gorilla major histocompatibility complex-DRB pseudogene orthologous to HLA-DRBVIII. In: Human Immunology. 1991 ; Vol. 32, No. 3. pp. 211-220.
@article{825ab43e50fd4cd28dbb12bac61e0d62,
title = "Gorilla major histocompatibility complex-DRB pseudogene orthologous to HLA-DRBVIII",
abstract = "The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for β chains of the αβ heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA DRw53 determinants, respectively; the DRBVII and DRBVIII are pseudogenes. We found and sequenced a gene closely related to HLA-DRBVIII in the genome of the lowland gorilla {"}Sylvia{"}. We designate this gene Gogo-DRB8. The close relationship between the two genes is indicated by the overall sequence similarity, the absence of recognizable exons 1 and 2 in both genes, the presence if two Alu repeats at corresponding positions, and high sequence similarity between corresponding repeats. The comparison with an outgroup (tamarin) gene and the functional counterparts of the DRB8 gene indicate that DRB8 emerged between 18 and 26 million years ago and became inactivated at the same time as or shortly after its creation. Hence DRB8 has probably existed as a pseudogene since the divergence of apes from Old World monkeys more than 20 million years ago. Human Immunology 32, 211-220 (1991).",
author = "Dagmar Klein and Vladimir Vincek and Masanori Kasahara and Christian Sch{\"o}nbach and Colm O'hUigin and Jan Klein",
year = "1991",
doi = "10.1016/0198-8859(91)90058-H",
language = "English",
volume = "32",
pages = "211--220",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Gorilla major histocompatibility complex-DRB pseudogene orthologous to HLA-DRBVIII

AU - Klein, Dagmar

AU - Vincek, Vladimir

AU - Kasahara, Masanori

AU - Schönbach, Christian

AU - O'hUigin, Colm

AU - Klein, Jan

PY - 1991

Y1 - 1991

N2 - The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for β chains of the αβ heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA DRw53 determinants, respectively; the DRBVII and DRBVIII are pseudogenes. We found and sequenced a gene closely related to HLA-DRBVIII in the genome of the lowland gorilla "Sylvia". We designate this gene Gogo-DRB8. The close relationship between the two genes is indicated by the overall sequence similarity, the absence of recognizable exons 1 and 2 in both genes, the presence if two Alu repeats at corresponding positions, and high sequence similarity between corresponding repeats. The comparison with an outgroup (tamarin) gene and the functional counterparts of the DRB8 gene indicate that DRB8 emerged between 18 and 26 million years ago and became inactivated at the same time as or shortly after its creation. Hence DRB8 has probably existed as a pseudogene since the divergence of apes from Old World monkeys more than 20 million years ago. Human Immunology 32, 211-220 (1991).

AB - The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for β chains of the αβ heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA DRw53 determinants, respectively; the DRBVII and DRBVIII are pseudogenes. We found and sequenced a gene closely related to HLA-DRBVIII in the genome of the lowland gorilla "Sylvia". We designate this gene Gogo-DRB8. The close relationship between the two genes is indicated by the overall sequence similarity, the absence of recognizable exons 1 and 2 in both genes, the presence if two Alu repeats at corresponding positions, and high sequence similarity between corresponding repeats. The comparison with an outgroup (tamarin) gene and the functional counterparts of the DRB8 gene indicate that DRB8 emerged between 18 and 26 million years ago and became inactivated at the same time as or shortly after its creation. Hence DRB8 has probably existed as a pseudogene since the divergence of apes from Old World monkeys more than 20 million years ago. Human Immunology 32, 211-220 (1991).

UR - http://www.scopus.com/inward/record.url?scp=0025946379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025946379&partnerID=8YFLogxK

U2 - 10.1016/0198-8859(91)90058-H

DO - 10.1016/0198-8859(91)90058-H

M3 - Article

VL - 32

SP - 211

EP - 220

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

IS - 3

ER -