Graphene-based materials for the fast removal of cytokines from blood plasma

Mykola Seredych, Bernard Haines, Viktoriia Sokolova, Paul Cheung, Fayan Meng, Lon Stone, Lyuba Mikhalovska, Sergey Mikhalovsky, Vadym N. Mochalin, Yury Gogotsi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

There is a range of medical conditions, which include acute organ failure, bacterial and viral infection, and sepsis, that result in overactivation of the inflammatory response of the organism and release of proinflammatory cytokines into the bloodstream. Fast removal of these cytokines from blood circulation could offer a potentially efficient treatment of such conditions. This study aims at the development and assessment of novel biocompatible graphene-based adsorbents for blood purification from proinflammatory cytokines. These graphene-based materials were chosen on the basis of their surface accessibility for small molecules further facilitated by the interlayer porosity, which is comparable to the size of the cytokine molecules to be adsorbed. Our preliminary results show that graphene nanoplatelets (GnP) exhibit high adsorption capacity, but they cannot be used in direct contact with blood due to the risk of small carbon particle release into the bloodstream. Granulation of GnP using poly(tetrafluoroethylene) as a binder eliminated an undesirable nanoparticle release without affecting the GnP surface accessibility for the cytokine molecules. The efficiency of proinflammatory cytokine removal was shown using a specially designed flow-through system. So far, GnP proved to be among the fastest acting and most efficient sorbents for cytokine removal identified to date, outperforming porous activated carbons and porous polymers.

Original languageEnglish
Pages (from-to)436-443
Number of pages8
JournalACS Applied Bio Materials
Volume1
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Graphite
Graphene
Blood
Cytokines
Plasmas
Molecules
Carbon
Granulation
Blood Circulation
Porosity
Hemodynamics
Virus Diseases
Sorbents
Polytetrafluoroethylenes
Bacterial Infections
Activated carbon
Nanoparticles
Adsorbents
Adsorption
Binders

Keywords

  • Adsorption
  • Cytokines
  • Graphene nanoplatelets
  • Human blood plasma
  • Sepsis

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

Cite this

Seredych, M., Haines, B., Sokolova, V., Cheung, P., Meng, F., Stone, L., ... Gogotsi, Y. (2018). Graphene-based materials for the fast removal of cytokines from blood plasma. ACS Applied Bio Materials, 1(2), 436-443. https://doi.org/10.1021/acsabm.8b00151

Graphene-based materials for the fast removal of cytokines from blood plasma. / Seredych, Mykola; Haines, Bernard; Sokolova, Viktoriia; Cheung, Paul; Meng, Fayan; Stone, Lon; Mikhalovska, Lyuba; Mikhalovsky, Sergey; Mochalin, Vadym N.; Gogotsi, Yury.

In: ACS Applied Bio Materials, Vol. 1, No. 2, 01.01.2018, p. 436-443.

Research output: Contribution to journalArticle

Seredych, M, Haines, B, Sokolova, V, Cheung, P, Meng, F, Stone, L, Mikhalovska, L, Mikhalovsky, S, Mochalin, VN & Gogotsi, Y 2018, 'Graphene-based materials for the fast removal of cytokines from blood plasma', ACS Applied Bio Materials, vol. 1, no. 2, pp. 436-443. https://doi.org/10.1021/acsabm.8b00151
Seredych M, Haines B, Sokolova V, Cheung P, Meng F, Stone L et al. Graphene-based materials for the fast removal of cytokines from blood plasma. ACS Applied Bio Materials. 2018 Jan 1;1(2):436-443. https://doi.org/10.1021/acsabm.8b00151
Seredych, Mykola ; Haines, Bernard ; Sokolova, Viktoriia ; Cheung, Paul ; Meng, Fayan ; Stone, Lon ; Mikhalovska, Lyuba ; Mikhalovsky, Sergey ; Mochalin, Vadym N. ; Gogotsi, Yury. / Graphene-based materials for the fast removal of cytokines from blood plasma. In: ACS Applied Bio Materials. 2018 ; Vol. 1, No. 2. pp. 436-443.
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