Abstract
The development of human gut microbiota begins as soon as the neonate leaves the protective environment of the uterus (or maybe in-utero) and is exposed to innumerable microorganisms from the mother as well as the surrounding environment. Concurrently, the host responses to these microbes during early life manifest during the development of an otherwise hitherto immature immune system. The human gut microbiome, which comprises an extremely diverse and complex community of microorganisms inhabiting the intestinal tract, keeps on fluctuating during different stages of life. While these deviations are largely natural, inevitable and benign, recent studies show that unsolicited perturbations in gut microbiota configuration could have strong impact on several features of host health and disease. Our microbiota undergoes the most prominent deviations during infancy and old age and, interestingly, our immune health is also in its weakest and most unstable state during these two critical stages of life, indicating that our microbiota and health develop and age hand-in-hand. However, the mechanisms underlying these interactions are only now beginning to be revealed. The present review summarizes the evidences related to the age-associated changes in intestinal microbiota and vice-versa, mechanisms involved in this bi-directional relationship, and the prospective for development of microbiota-based interventions such as probiotics for healthy aging.
| Original language | English |
|---|---|
| Pages (from-to) | 267-285 |
| Number of pages | 19 |
| Journal | Nutrition and Healthy Aging |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
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Keywords
- Aging
- enteric nervous system
- gut dysbiosis
- gut permeability
- intestinal microbiota
- metabolic inflammation
- prebiotics
- probiotics
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
- Biochemistry
- Nutrition and Dietetics
Cite this
Gut microbiome and aging : Physiological and mechanistic insights. / Nagpal, Ravinder; Mainali, Rabina; Ahmadi, Shokouh; Wang, Shaohua; Singh, Ria; Kavanagh, Kylie; Kitzman, Dalane W.; Kushugulova, Almagul; Marotta, Francesco; Yadav, Hariom.
In: Nutrition and Healthy Aging, Vol. 4, No. 4, 01.01.2018, p. 267-285.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Gut microbiome and aging
T2 - Physiological and mechanistic insights
AU - Nagpal, Ravinder
AU - Mainali, Rabina
AU - Ahmadi, Shokouh
AU - Wang, Shaohua
AU - Singh, Ria
AU - Kavanagh, Kylie
AU - Kitzman, Dalane W.
AU - Kushugulova, Almagul
AU - Marotta, Francesco
AU - Yadav, Hariom
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The development of human gut microbiota begins as soon as the neonate leaves the protective environment of the uterus (or maybe in-utero) and is exposed to innumerable microorganisms from the mother as well as the surrounding environment. Concurrently, the host responses to these microbes during early life manifest during the development of an otherwise hitherto immature immune system. The human gut microbiome, which comprises an extremely diverse and complex community of microorganisms inhabiting the intestinal tract, keeps on fluctuating during different stages of life. While these deviations are largely natural, inevitable and benign, recent studies show that unsolicited perturbations in gut microbiota configuration could have strong impact on several features of host health and disease. Our microbiota undergoes the most prominent deviations during infancy and old age and, interestingly, our immune health is also in its weakest and most unstable state during these two critical stages of life, indicating that our microbiota and health develop and age hand-in-hand. However, the mechanisms underlying these interactions are only now beginning to be revealed. The present review summarizes the evidences related to the age-associated changes in intestinal microbiota and vice-versa, mechanisms involved in this bi-directional relationship, and the prospective for development of microbiota-based interventions such as probiotics for healthy aging.
AB - The development of human gut microbiota begins as soon as the neonate leaves the protective environment of the uterus (or maybe in-utero) and is exposed to innumerable microorganisms from the mother as well as the surrounding environment. Concurrently, the host responses to these microbes during early life manifest during the development of an otherwise hitherto immature immune system. The human gut microbiome, which comprises an extremely diverse and complex community of microorganisms inhabiting the intestinal tract, keeps on fluctuating during different stages of life. While these deviations are largely natural, inevitable and benign, recent studies show that unsolicited perturbations in gut microbiota configuration could have strong impact on several features of host health and disease. Our microbiota undergoes the most prominent deviations during infancy and old age and, interestingly, our immune health is also in its weakest and most unstable state during these two critical stages of life, indicating that our microbiota and health develop and age hand-in-hand. However, the mechanisms underlying these interactions are only now beginning to be revealed. The present review summarizes the evidences related to the age-associated changes in intestinal microbiota and vice-versa, mechanisms involved in this bi-directional relationship, and the prospective for development of microbiota-based interventions such as probiotics for healthy aging.
KW - Aging
KW - enteric nervous system
KW - gut dysbiosis
KW - gut permeability
KW - intestinal microbiota
KW - metabolic inflammation
KW - prebiotics
KW - probiotics
UR - http://www.scopus.com/inward/record.url?scp=85048722540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048722540&partnerID=8YFLogxK
U2 - 10.3233/NHA-170030
DO - 10.3233/NHA-170030
M3 - Review article
VL - 4
SP - 267
EP - 285
JO - Nutrition and Healthy Aging
JF - Nutrition and Healthy Aging
SN - 2451-9480
IS - 4
ER -