Gut microbiome diversity in kazakhstani women of different age groups

Dinara Baiskhanova, Almagul Kushugulova, Samat Kozhakhmetov, Zhanagul Khassenbekova, Talgat Nurgozhin, Francesco Marotta, Zhaxybay Zhumadilov

Research output: Contribution to journalArticle

1 Citation (Scopus)
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Abstract

Human gut microflora includes three enterotypes and composes the largest part of the whole microbiome. Because gut microflora play a crucial role in health and disease, knowing the microbial composition of the gut microbiome is an important task. Currently, the gut microbiome composition in the Kazakhstani population is poorly understood. Therefore, we studied the phylogenetic composition and types of the gut microbiome in Kazakhstani women and stratified the data by age. Female subjects were divided into three groups: six young (<44 years old), eighteen middle-aged (50–70 years old), and six elderly (>90 years old). For the gut microbiome composition analysis, the 16S rDNA locus was amplified, ligated into high copy plasmid vectors, and sequenced. We observed that two gut microbiome types, Phyla Bacteroidetes and Firmicutes, were age independent. However, there were significant differences in species composition between groups that can be attributed to age. The highest species diversity occurred in the middle-aged group, which subsequently decreased in the elderly group.
Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalInternational Journal of Probiotics and Prebiotics
Publication statusPublished - 2015

Keywords

  • Age, Compositional structure, Diversity, Gut, Microbiome, Species

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