Gut-targeted immunonutrition boosting natural killer cell activity using saccharomyces boulardii lysates in immuno-compromised healthy elderly subjects

Yasuhiro Naito, Francesco Marotta, Makoto K. Kantah, Nicola Zerbinati, Almagul Kushugulova, Zhaxybay Zhumadilov, Nicola Illuzzi, Chiara Sapienza, Hiroshi Takadanohara, Riyichi Kobayashi, Roberto Catanzaro

Research output: Contribution to journalArticle

Abstract

The aim of this study was to assess the immunomodulatory effect of KC-1317 (a symbiotic mixture containing Saccharomyces boulardii lysate in a cranberry, colostrum-derived lactoferrin, fragaria, and lactose mixture) supplementation in immune-compromised but otherwise healthy elderly subjects. A liquid formulation of KC-1317 was administered in a randomized controlled trial (RCT) fashion to healthy volunteers (65-79 years) previously selected for low natural killer (NK) cell activity, and this parameter was checked at the completion of the study. A significant improvement in NK cell activity of KC-1317 consumers was observed as compared to placebo at the end of 2 months. Although preliminary, these beneficial immune-modulatory effects of KC-1317 in aged individuals might indicate its employment within a wider age-management strategy.

Original languageEnglish
Pages (from-to)184-187
Number of pages4
JournalRejuvenation Research
Volume17
Issue number2
DOIs
Publication statusPublished - Apr 1 2014

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Natural Killer Cells
Healthy Volunteers
Vaccinium macrocarpon
Fragaria
Colostrum
Lactoferrin
Lactose
Randomized Controlled Trials
Placebos
Saccharomyces boulardii

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Gut-targeted immunonutrition boosting natural killer cell activity using saccharomyces boulardii lysates in immuno-compromised healthy elderly subjects. / Naito, Yasuhiro; Marotta, Francesco; Kantah, Makoto K.; Zerbinati, Nicola; Kushugulova, Almagul; Zhumadilov, Zhaxybay; Illuzzi, Nicola; Sapienza, Chiara; Takadanohara, Hiroshi; Kobayashi, Riyichi; Catanzaro, Roberto.

In: Rejuvenation Research, Vol. 17, No. 2, 01.04.2014, p. 184-187.

Research output: Contribution to journalArticle

Naito, Yasuhiro ; Marotta, Francesco ; Kantah, Makoto K. ; Zerbinati, Nicola ; Kushugulova, Almagul ; Zhumadilov, Zhaxybay ; Illuzzi, Nicola ; Sapienza, Chiara ; Takadanohara, Hiroshi ; Kobayashi, Riyichi ; Catanzaro, Roberto. / Gut-targeted immunonutrition boosting natural killer cell activity using saccharomyces boulardii lysates in immuno-compromised healthy elderly subjects. In: Rejuvenation Research. 2014 ; Vol. 17, No. 2. pp. 184-187.
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