The goal of this chapter is to provide students with the basics of health, safety and environment (HSE) activities in conceptual process design. The first section describes the impact factors, associated toxicological and physical properties, as well as estimation methods assisted by computer simulation. These properties are gathered in a compulsory document for design, manufacturing and use of a chemical product that is the material safety data sheet. The most efficient treatment of HSE issues is at the conceptual design stage, when the process modifications have the strongest effect. The goal is achieving inherently safer design. The protection of the equipment by safety valves is shortly presented. This chapter ends with the most commonly employed methods in industry for the assessment and management of potential risks, such as the Dow Fire and Explosion Index and hazard and operability study.