Biobutanol is a renewable fuel produced nowadays from waste biomass feedstocks. It features low water miscibility, flammability, corrosiveness, with the additional advantage that it can replace gasoline in cars, without any engine modifications. The butanol obtained after the fermentation step has a low concentration (typically less than 3 %wt) that leads to high energy requirements for conventional downstream separation. To overcome this issue, we propose here a novel hybrid separation process based on a heat pump assisted azeotropic dividing-wall column (A-DWC). CAPE tools and Pinch analysis have been used for the process synthesis, design and optimization of the process. The plant capacity considered here is 40 ktpy butanol (99.4 %wt). Remarkably, the energy requirement for butanol separation using heat integration and vapour recompression assisted A-DWC is reduced by 58 % from 6.3 to 2.7 MJ/kg butanol.