Hepatic histopathological findings in HIV patients at postmortem in Jos university teaching hospital, Nigeria

Godwins O. Echejoh, Barnabas M. Mandong, Matthew N. Tanko, Agabus N. Manasseh, Edith N. Okeke, Emmanuel I. Agaba

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Multi-organ involvement by opportunistic infections and neoplasms is the major cause of morbidity and mortality in people living with HIV/AIDS. We determined the spectrum/frequency of hepatic histopathological lesions in a prospective study of postmortem liver biopsies from 100 patients (50 females and 50 males, age range 18-55 years) who died from HIV/AIDS in Jos university teaching hospital, Nigeria. The majority of the patients, 65 (65%), had clinical tuberculosis. Granulomatous hepatitis, chronic hepatitis, non-specific reactive hepatitis (NSRH) and steatosis were the commonest hepatic histopathologic lesions occurring in 34, 20,15 and 12% of patients, respectively. Seven (7%) had normal histological features. This study shows that the liver is affected in HIV/AIDS as reported elsewhere in the world. Therefore, liver biopsy in HIV patients may be helpful in the management of these patients.

Original languageEnglish
Pages (from-to)228-231
Number of pages4
JournalTropical Doctor
Volume36
Issue number4
DOIs
Publication statusPublished - Oct 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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