TY - JOUR
T1 - Hepatic histopathological findings in HIV patients at postmortem in Jos university teaching hospital, Nigeria
AU - Echejoh, Godwins O.
AU - Mandong, Barnabas M.
AU - Tanko, Matthew N.
AU - Manasseh, Agabus N.
AU - Okeke, Edith N.
AU - Agaba, Emmanuel I.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2006/10/1
Y1 - 2006/10/1
N2 - Multi-organ involvement by opportunistic infections and neoplasms is the major cause of morbidity and mortality in people living with HIV/AIDS. We determined the spectrum/frequency of hepatic histopathological lesions in a prospective study of postmortem liver biopsies from 100 patients (50 females and 50 males, age range 18-55 years) who died from HIV/AIDS in Jos university teaching hospital, Nigeria. The majority of the patients, 65 (65%), had clinical tuberculosis. Granulomatous hepatitis, chronic hepatitis, non-specific reactive hepatitis (NSRH) and steatosis were the commonest hepatic histopathologic lesions occurring in 34, 20,15 and 12% of patients, respectively. Seven (7%) had normal histological features. This study shows that the liver is affected in HIV/AIDS as reported elsewhere in the world. Therefore, liver biopsy in HIV patients may be helpful in the management of these patients.
AB - Multi-organ involvement by opportunistic infections and neoplasms is the major cause of morbidity and mortality in people living with HIV/AIDS. We determined the spectrum/frequency of hepatic histopathological lesions in a prospective study of postmortem liver biopsies from 100 patients (50 females and 50 males, age range 18-55 years) who died from HIV/AIDS in Jos university teaching hospital, Nigeria. The majority of the patients, 65 (65%), had clinical tuberculosis. Granulomatous hepatitis, chronic hepatitis, non-specific reactive hepatitis (NSRH) and steatosis were the commonest hepatic histopathologic lesions occurring in 34, 20,15 and 12% of patients, respectively. Seven (7%) had normal histological features. This study shows that the liver is affected in HIV/AIDS as reported elsewhere in the world. Therefore, liver biopsy in HIV patients may be helpful in the management of these patients.
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U2 - 10.1258/004947506778604832
DO - 10.1258/004947506778604832
M3 - Article
C2 - 17034701
AN - SCOPUS:33750091624
SN - 0049-4755
VL - 36
SP - 228
EP - 231
JO - Tropical Doctor
JF - Tropical Doctor
IS - 4
ER -
