Hepatitis a virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage

P. Karayiannis, T. Jowett, M. Enticott, D. Moore, M. Pignatelli, F. Brenes, P. J. Scheuer, H. C. Thomas

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Hepatitis A virus (HAV) shedding in the faeces, appearance of HAV-Ag (antigen) in the liver, and development of humoral immunity to HAV have been studied in experimentally infected tamarins. The appearance of liver damage measured by transaminase elevation and histology, in relation to the above variables, suggests that the virus is not cytopathic and the immune system contributes to the production of liver cell damage. Preliminary data suggest that HAV replication may occur in the mucosa of the small intestine and in the liver.r113w1.w2 = +sd tamarin

Original languageEnglish
Pages (from-to)261-276
Number of pages16
JournalJournal of Medical Virology
Volume18
Issue number3
Publication statusPublished - 1986
Externally publishedYes

Fingerprint

Hepatitis Viruses
Virus Replication
Hepatitis A virus
Liver
Hepatitis A Antigens
Virus Shedding
Humoral Immunity
Transaminases
Feces
Small Intestine
Immune System
Histology
Mucous Membrane
Viruses

ASJC Scopus subject areas

  • Virology

Cite this

Karayiannis, P., Jowett, T., Enticott, M., Moore, D., Pignatelli, M., Brenes, F., ... Thomas, H. C. (1986). Hepatitis a virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage. Journal of Medical Virology, 18(3), 261-276.

Hepatitis a virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage. / Karayiannis, P.; Jowett, T.; Enticott, M.; Moore, D.; Pignatelli, M.; Brenes, F.; Scheuer, P. J.; Thomas, H. C.

In: Journal of Medical Virology, Vol. 18, No. 3, 1986, p. 261-276.

Research output: Contribution to journalArticle

Karayiannis, P, Jowett, T, Enticott, M, Moore, D, Pignatelli, M, Brenes, F, Scheuer, PJ & Thomas, HC 1986, 'Hepatitis a virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage', Journal of Medical Virology, vol. 18, no. 3, pp. 261-276.
Karayiannis, P. ; Jowett, T. ; Enticott, M. ; Moore, D. ; Pignatelli, M. ; Brenes, F. ; Scheuer, P. J. ; Thomas, H. C. / Hepatitis a virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage. In: Journal of Medical Virology. 1986 ; Vol. 18, No. 3. pp. 261-276.
@article{c14695cfa5e64ff580023efc8985442e,
title = "Hepatitis a virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage",
abstract = "Hepatitis A virus (HAV) shedding in the faeces, appearance of HAV-Ag (antigen) in the liver, and development of humoral immunity to HAV have been studied in experimentally infected tamarins. The appearance of liver damage measured by transaminase elevation and histology, in relation to the above variables, suggests that the virus is not cytopathic and the immune system contributes to the production of liver cell damage. Preliminary data suggest that HAV replication may occur in the mucosa of the small intestine and in the liver.r113w1.w2 = +sd tamarin",
author = "P. Karayiannis and T. Jowett and M. Enticott and D. Moore and M. Pignatelli and F. Brenes and Scheuer, {P. J.} and Thomas, {H. C.}",
year = "1986",
language = "English",
volume = "18",
pages = "261--276",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Hepatitis a virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage

AU - Karayiannis, P.

AU - Jowett, T.

AU - Enticott, M.

AU - Moore, D.

AU - Pignatelli, M.

AU - Brenes, F.

AU - Scheuer, P. J.

AU - Thomas, H. C.

PY - 1986

Y1 - 1986

N2 - Hepatitis A virus (HAV) shedding in the faeces, appearance of HAV-Ag (antigen) in the liver, and development of humoral immunity to HAV have been studied in experimentally infected tamarins. The appearance of liver damage measured by transaminase elevation and histology, in relation to the above variables, suggests that the virus is not cytopathic and the immune system contributes to the production of liver cell damage. Preliminary data suggest that HAV replication may occur in the mucosa of the small intestine and in the liver.r113w1.w2 = +sd tamarin

AB - Hepatitis A virus (HAV) shedding in the faeces, appearance of HAV-Ag (antigen) in the liver, and development of humoral immunity to HAV have been studied in experimentally infected tamarins. The appearance of liver damage measured by transaminase elevation and histology, in relation to the above variables, suggests that the virus is not cytopathic and the immune system contributes to the production of liver cell damage. Preliminary data suggest that HAV replication may occur in the mucosa of the small intestine and in the liver.r113w1.w2 = +sd tamarin

UR - http://www.scopus.com/inward/record.url?scp=0022647854&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022647854&partnerID=8YFLogxK

M3 - Article

VL - 18

SP - 261

EP - 276

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 3

ER -