Herbal Substances with Antiviral Effects: Features and Prospects for the Treatment of Viral Diseases with Emphasis on Pro-Inflammatory Cytokines

Geir Bjørklund, Roman Lysiuk, Yuliya Semenova, Larysa Lenchyk, Natalia Dub, Monica Daniela Doşa, Tony Hangan

Research output: Contribution to journalArticlepeer-review

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the coronavirus family and could induce the viral disease named coronavirus disease 2019 (COVID-19). The disease became a pandemic after the reported first case in December 2019. In this review, we highlighted the herbal substances with antiviral effects. To examine peer-review publications dealing with the features and prospects for COVID-19 treatment with an emphasis on pro-inflammatory cytokines, we conducted electronic and full-text searches of Science Direct, CABI Direct, Web of Science, PubMed, and Scopus databases. Cytokine storm mechanisms are factors that induce a pro-inflammatory response, including the expression of cytokines and chemokines. The subsequent leukocyte recruitment and antiviral effect or functions contribute to the first line of defense against viruses. There have been numerous investigations with herbal medicine candidates used as immunomodulators or antivirals. However, cytokine-storm-targeted therapy was recommended to SARS-CoV patients with acute respiratory distress syndrome leading to severe pulmonary failure. These reviews showed that herbal formulations as alternative medicine might significantly reduce complicated viral infections and hold promising specific antiviral on experimental animal models.

Original languageEnglish
JournalCurrent Medicinal Chemistry
DOIs
Publication statusE-pub ahead of print - Jan 25 2023

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