Heterochromatin and the molecular mechanisms of 'parent-of-origin' effects in animals

Prim B Singh

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Twenty five years ago it was proposed that conserved components of constitutive heterochromatin assemble heterochromatinlike complexes in euchromatin and this could provide a general mechanism for regulating heritable (cell-to-cell) changes in gene expressibility. As a special case, differences in the assembly of heterochromatin-like complexes on homologous chromosomes might also regulate the parent-of-origin-dependent gene expression observed in placental mammals. Here, the progress made in the intervening period with emphasis on the role of heterochromatin and heterochromatin-like complexes in parent-of-origin effects in animals is reviewed.

Original languageEnglish
Pages (from-to)759-786
Number of pages28
JournalJournal of Biosciences
Volume41
Issue number4
Publication statusPublished - Dec 2016
Externally publishedYes

Keywords

  • Animals
  • Euchromatin
  • Gene Expression Regulation
  • Heterochromatin
  • Mammals
  • Journal Article
  • Review

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