High levels of oestrogen receptor-α in tumorigenesis: Inhibition of cell growth and angiogenic factors

S. H. Ali, A. L. O'Donnell, D. Balu, M. B. Pohl, M. J. Seyler, S. Mohamed, S. Mousa, P. Dandona

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Abstract

We previously found that the stable overexpression of oestrogen receptor-α in the human endothelial cell line ECV304* inhibits its growth in vitro, and that this inhibition is possibly mediated through a down-regulation of the vasoactive agents endothelin-1 and vascular endothelial growth factor. Here we show an in vivo growth-inhibitory effect of oestrogen receptor-α overexpression in tumours initiated in nude mice from the same clone of ECV304. In addition, we show that this growth inhibition is accompanied by an αvβ3-mediated inhibition of cell migration in vitro, and a down-regulation of the integrin αvβ3, vascular endothelial growth factor and vascularization in vivo. The levels of vascular endothelial growth factor and integrin αvβ3, through their effect on cell growth and migration, contribute to the process of angiogenesis and to the pathogenesis of atherosclerosis and cancer. The results shown here demonstrate that a higher level of oestrogen receptor-α in the cell, through its effect on certain angiogenic factors, may play a role in the control of angiogenesis.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalCell Proliferation
Volume34
Issue number4
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Cell Biology

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    Ali, S. H., O'Donnell, A. L., Balu, D., Pohl, M. B., Seyler, M. J., Mohamed, S., Mousa, S., & Dandona, P. (2001). High levels of oestrogen receptor-α in tumorigenesis: Inhibition of cell growth and angiogenic factors. Cell Proliferation, 34(4), 223-231. https://doi.org/10.1046/j.0960-7722.2001.00207.x