Highly efficient CT contrast agent based on barium-doped mesoporous silica nanoparticles (SiO2-Ba NPs)

Akbota Mazhit; Kamila Zhumanova; Bakyt Duisenbayeva; Timur Sh Atabaev

doi:10.1016/j.matlet.2023.135318

Highly efficient CT contrast agent based on barium-doped mesoporous silica nanoparticles (SiO₂-Ba NPs)

Akbota Mazhit, Kamila Zhumanova, Bakyt Duisenbayeva, Timur Sh Atabaev

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of nanoparticles-based contrast agents (CA) has gained momentum in recent years due to their superior contrasting properties over conventional molecular counterparts. Herein, for the first time, we present the synthesis and contrasting properties evaluation of small (<50 nm) barium-doped mesoporous silica nanoparticles (SiO₂-Ba NPs). We found that the X-ray attenuation efficiency of SiO₂-Ba NPs was ∼4.5 times higher than that of a medically-employed Iopromide contrast agent under the same conditions. A leaching test revealed that the maximum level of Ba²⁺ ions escape was negligible indicating that the prepared SiO₂-Ba NPs are structurally stable. Overall, the prepared SiO₂-Ba NPs show great promise as effective CT contrast agents.

Original language	English
Article number	135318
Journal	Materials Letters
Volume	353
DOIs	https://doi.org/10.1016/j.matlet.2023.135318
Publication status	Published - Dec 15 2023

Keywords

Biomaterials
Nanoparticles
Porous materials
Powder technology

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1016/j.matlet.2023.135318

Cite this

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title = "Highly efficient CT contrast agent based on barium-doped mesoporous silica nanoparticles (SiO2-Ba NPs)",

abstract = "The synthesis of nanoparticles-based contrast agents (CA) has gained momentum in recent years due to their superior contrasting properties over conventional molecular counterparts. Herein, for the first time, we present the synthesis and contrasting properties evaluation of small (<50 nm) barium-doped mesoporous silica nanoparticles (SiO2-Ba NPs). We found that the X-ray attenuation efficiency of SiO2-Ba NPs was ∼4.5 times higher than that of a medically-employed Iopromide contrast agent under the same conditions. A leaching test revealed that the maximum level of Ba2+ ions escape was negligible indicating that the prepared SiO2-Ba NPs are structurally stable. Overall, the prepared SiO2-Ba NPs show great promise as effective CT contrast agents.",

keywords = "Biomaterials, Nanoparticles, Porous materials, Powder technology",

author = "Akbota Mazhit and Kamila Zhumanova and Bakyt Duisenbayeva and Atabaev, {Timur Sh}",

note = "Funding Information: This research was funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (Grant No. AP19578878 ). ",

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doi = "10.1016/j.matlet.2023.135318",

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TY - JOUR

T1 - Highly efficient CT contrast agent based on barium-doped mesoporous silica nanoparticles (SiO2-Ba NPs)

AU - Mazhit, Akbota

AU - Zhumanova, Kamila

AU - Duisenbayeva, Bakyt

AU - Atabaev, Timur Sh

N1 - Funding Information: This research was funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (Grant No. AP19578878 ).

PY - 2023/12/15

Y1 - 2023/12/15

N2 - The synthesis of nanoparticles-based contrast agents (CA) has gained momentum in recent years due to their superior contrasting properties over conventional molecular counterparts. Herein, for the first time, we present the synthesis and contrasting properties evaluation of small (<50 nm) barium-doped mesoporous silica nanoparticles (SiO2-Ba NPs). We found that the X-ray attenuation efficiency of SiO2-Ba NPs was ∼4.5 times higher than that of a medically-employed Iopromide contrast agent under the same conditions. A leaching test revealed that the maximum level of Ba2+ ions escape was negligible indicating that the prepared SiO2-Ba NPs are structurally stable. Overall, the prepared SiO2-Ba NPs show great promise as effective CT contrast agents.

AB - The synthesis of nanoparticles-based contrast agents (CA) has gained momentum in recent years due to their superior contrasting properties over conventional molecular counterparts. Herein, for the first time, we present the synthesis and contrasting properties evaluation of small (<50 nm) barium-doped mesoporous silica nanoparticles (SiO2-Ba NPs). We found that the X-ray attenuation efficiency of SiO2-Ba NPs was ∼4.5 times higher than that of a medically-employed Iopromide contrast agent under the same conditions. A leaching test revealed that the maximum level of Ba2+ ions escape was negligible indicating that the prepared SiO2-Ba NPs are structurally stable. Overall, the prepared SiO2-Ba NPs show great promise as effective CT contrast agents.

KW - Biomaterials

KW - Nanoparticles

KW - Porous materials

KW - Powder technology

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