Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

Timo Burster, Zhadyra Mustafa, Dinara Myrzakhmetova, Anuar Zhanapiya, Michal Zimecki

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.

Original languageEnglish
Pages (from-to)784003
JournalFrontiers in Chemistry
Volume9
DOIs
Publication statusPublished - 2021

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