Histogenesis of haemangioblastomas

An immunocytochemical and ultrastructural study in a case of von Hippel-Lindau syndrome

S. M. Ismail, B. Jasani, G. Cole

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The cerebellar, retinal, and one of the spinal haemangioblastomas in a case of von Hippel-Lindau syndrome were studied by immunocytochemistry and electron microscopy. The tumours were positive for neurone specific enolase and variably positive for somatostatin, pancreatic polypeptide, and bombesin. Electron microscopy of the cerebellar tumour showed secretory granules with an average diameter of 170 nm. This report is believed to be the first description of neurone specific enolase positivity and polypeptide hormones within the intervascular cells of haemangioblastomas. In the light of these findings it is suggested that haemangioblastomas are tumours of neuroectodermal origin, derived either from neural or neuroendocrine cells.

Original languageEnglish
Pages (from-to)417-421
Number of pages5
JournalJournal of Clinical Pathology
Volume38
Issue number4
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

Hemangioblastoma
von Hippel-Lindau Disease
Phosphopyruvate Hydratase
Electron Microscopy
Cerebellar Neoplasms
Neuroectodermal Tumors
Pancreatic Polypeptide
Bombesin
Neuroendocrine Cells
Peptide Hormones
Secretory Vesicles
Somatostatin
Immunohistochemistry
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Histogenesis of haemangioblastomas : An immunocytochemical and ultrastructural study in a case of von Hippel-Lindau syndrome. / Ismail, S. M.; Jasani, B.; Cole, G.

In: Journal of Clinical Pathology, Vol. 38, No. 4, 1985, p. 417-421.

Research output: Contribution to journalArticle

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