Abstract
The cerebellar, retinal, and one of the spinal haemangioblastomas in a case of von Hippel-Lindau syndrome were studied by immunocytochemistry and electron microscopy. The tumours were positive for neurone specific enolase and variably positive for somatostatin, pancreatic polypeptide, and bombesin. Electron microscopy of the cerebellar tumour showed secretory granules with an average diameter of 170 nm. This report is believed to be the first description of neurone specific enolase positivity and polypeptide hormones within the intervascular cells of haemangioblastomas. In the light of these findings it is suggested that haemangioblastomas are tumours of neuroectodermal origin, derived either from neural or neuroendocrine cells.
| Original language | English |
|---|---|
| Pages (from-to) | 417-421 |
| Number of pages | 5 |
| Journal | Journal of Clinical Pathology |
| Volume | 38 |
| Issue number | 4 |
| Publication status | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
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Histogenesis of haemangioblastomas : An immunocytochemical and ultrastructural study in a case of von Hippel-Lindau syndrome. / Ismail, S. M.; Jasani, B.; Cole, G.
In: Journal of Clinical Pathology, Vol. 38, No. 4, 1985, p. 417-421.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Histogenesis of haemangioblastomas
T2 - An immunocytochemical and ultrastructural study in a case of von Hippel-Lindau syndrome
AU - Ismail, S. M.
AU - Jasani, B.
AU - Cole, G.
PY - 1985
Y1 - 1985
N2 - The cerebellar, retinal, and one of the spinal haemangioblastomas in a case of von Hippel-Lindau syndrome were studied by immunocytochemistry and electron microscopy. The tumours were positive for neurone specific enolase and variably positive for somatostatin, pancreatic polypeptide, and bombesin. Electron microscopy of the cerebellar tumour showed secretory granules with an average diameter of 170 nm. This report is believed to be the first description of neurone specific enolase positivity and polypeptide hormones within the intervascular cells of haemangioblastomas. In the light of these findings it is suggested that haemangioblastomas are tumours of neuroectodermal origin, derived either from neural or neuroendocrine cells.
AB - The cerebellar, retinal, and one of the spinal haemangioblastomas in a case of von Hippel-Lindau syndrome were studied by immunocytochemistry and electron microscopy. The tumours were positive for neurone specific enolase and variably positive for somatostatin, pancreatic polypeptide, and bombesin. Electron microscopy of the cerebellar tumour showed secretory granules with an average diameter of 170 nm. This report is believed to be the first description of neurone specific enolase positivity and polypeptide hormones within the intervascular cells of haemangioblastomas. In the light of these findings it is suggested that haemangioblastomas are tumours of neuroectodermal origin, derived either from neural or neuroendocrine cells.
UR - http://www.scopus.com/inward/record.url?scp=0021929170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021929170&partnerID=8YFLogxK
M3 - Article
C2 - 2859302
AN - SCOPUS:0021929170
VL - 38
SP - 417
EP - 421
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 4
ER -