TY - JOUR
T1 - History, challenges and perspectives of cell microencapsulation
AU - Orive, Gorka
AU - Hernández, Rose Maria
AU - Rodríguez Gascón, Alicia
AU - Calafiore, Riccardo
AU - Chang, Thomas Ming Swi
AU - De Vos, Paul
AU - Hortelano, Gonzalo
AU - Hunkeler, David
AU - Lacík, Igor
AU - Pedraz, José Luis
PY - 2004/2
Y1 - 2004/2
N2 - Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products to the host by immunoisolated cells is a potentially cost-effective method to treat a wide range of diseases. Although there are several issues that need to be addressed, including capsule manufacture, properties and performance, in the past few years, a stepwise analysis on the essential obstacles and limitations has brought the whole technology closer to a realistic proposal for clinical application. This paper summarizes the current situation in the cell encapsulation field and discusses the main events that have occurred along the way.
AB - Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products to the host by immunoisolated cells is a potentially cost-effective method to treat a wide range of diseases. Although there are several issues that need to be addressed, including capsule manufacture, properties and performance, in the past few years, a stepwise analysis on the essential obstacles and limitations has brought the whole technology closer to a realistic proposal for clinical application. This paper summarizes the current situation in the cell encapsulation field and discusses the main events that have occurred along the way.
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U2 - 10.1016/j.tibtech.2003.11.004
DO - 10.1016/j.tibtech.2003.11.004
M3 - Review article
C2 - 14757043
AN - SCOPUS:9144263544
SN - 0167-7799
VL - 22
SP - 87
EP - 92
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 2
ER -