History, challenges and perspectives of cell microencapsulation

Gorka Orive, Rose Maria Hernández, Alicia Rodríguez Gascón, Riccardo Calafiore, Thomas Ming Swi Chang, Paul De Vos, Gonzalo Hortelano, David Hunkeler, Igor Lacík, José Luis Pedraz

Research output: Contribution to journalReview articlepeer-review

293 Citations (Scopus)


Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products to the host by immunoisolated cells is a potentially cost-effective method to treat a wide range of diseases. Although there are several issues that need to be addressed, including capsule manufacture, properties and performance, in the past few years, a stepwise analysis on the essential obstacles and limitations has brought the whole technology closer to a realistic proposal for clinical application. This paper summarizes the current situation in the cell encapsulation field and discusses the main events that have occurred along the way.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalTrends in Biotechnology
Issue number2
Publication statusPublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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