Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 554-565 |
| Number of pages | 12 |
| Journal | Transplant International |
| Volume | 31 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2018 |
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Keywords
- mycophenolic acid
- tacrolimus, adult
- African American
- age distribution
- all cause mortality
- Article
- Caucasian
- controlled study
- disease association
- female
- graft failure
- graft rejection
- human
- kidney transplantation
- major clinical study
- male
- mania
- medication compliance
- priority journal
- psychosis
- risk assessment
- risk factor
- sex difference
- treatment outcome
- veteran
- aged
- bipolar disorder
- cause of death
- complication
- middle aged
- mortality
- retrospective study, Aged
- Bipolar Disorder
- Cause of Death
- Female
- Graft Rejection
- Humans
- Kidney Transplantation
- Male
- Medication Adherence
- Middle Aged
- Psychotic Disorders
- Retrospective Studies
Cite this
History of psychosis and mania, and outcomes after kidney transplantation - a retrospective study. / Molnar, M.Z.; Eason, J.D.; Gaipov, A.; Talwar, M.; Potukuchi, P.K.; Joglekar, K.; Remport, A.; Mathe, Z.; Mucsi, I.; Novak, M.; Kalantar-Zadeh, K.; Kovesdy, C.P.
In: Transplant International, Vol. 31, No. 5, 2018, p. 554-565.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - History of psychosis and mania, and outcomes after kidney transplantation - a retrospective study
AU - Molnar, M.Z.
AU - Eason, J.D.
AU - Gaipov, A.
AU - Talwar, M.
AU - Potukuchi, P.K.
AU - Joglekar, K.
AU - Remport, A.
AU - Mathe, Z.
AU - Mucsi, I.
AU - Novak, M.
AU - Kalantar-Zadeh, K.
AU - Kovesdy, C.P.
N1 - cited By 0
PY - 2018
Y1 - 2018
N2 - History of psychosis or mania, if uncontrolled, both represent relative contraindications for kidney transplantation. We examined 3680 US veterans who underwent kidney transplantation. The diagnosis of history of psychosis/mania was based on a validated algorithm. Measured confounders were used to create a propensity score-matched cohort (n = 442). Associations between pretransplantation psychosis/mania and death with functioning graft, all-cause death, graft loss, and rejection were examined in survival models and logistic regression models. Post-transplant medication nonadherence was assessed using proportion of days covered (PDC) for tacrolimus and mycophenolic acid in both groups. The mean ± SD age of the cohort at baseline was 61 ± 11 years, 92% were male, and 66% and 27% of patients were white and African-American, respectively. Compared to patients without history of psychosis/mania, patients with a history of psychosis/mania had similar risk of death with functioning graft [subhazard ratio (SHR) (95% confidence interval (CI)): 0.94(0.42–2.09)], all-cause death [hazard ratio (95% CI): 1.04 (0.51–2.14)], graft loss [SHR (95% CI): 1.07 (0.45–2.57)], and rejection [odds ratio(95% CI): 1.23(0.60–2.53)]. Moreover, there was no difference in immunosuppressive drug PDC in patients with and without history of psychosis/mania (PDC: 76 ± 21% vs. 78 ± 19%, P = 0.529 for tacrolimus; PDC: 78 ± 17% vs. 79 ± 18%, P = 0.666 for mycophenolic acid). After careful selection, pretransplantation psychosis/mania is not associated with adverse outcomes in kidney transplant recipients. © 2018 Steunstichting ESOT
AB - History of psychosis or mania, if uncontrolled, both represent relative contraindications for kidney transplantation. We examined 3680 US veterans who underwent kidney transplantation. The diagnosis of history of psychosis/mania was based on a validated algorithm. Measured confounders were used to create a propensity score-matched cohort (n = 442). Associations between pretransplantation psychosis/mania and death with functioning graft, all-cause death, graft loss, and rejection were examined in survival models and logistic regression models. Post-transplant medication nonadherence was assessed using proportion of days covered (PDC) for tacrolimus and mycophenolic acid in both groups. The mean ± SD age of the cohort at baseline was 61 ± 11 years, 92% were male, and 66% and 27% of patients were white and African-American, respectively. Compared to patients without history of psychosis/mania, patients with a history of psychosis/mania had similar risk of death with functioning graft [subhazard ratio (SHR) (95% confidence interval (CI)): 0.94(0.42–2.09)], all-cause death [hazard ratio (95% CI): 1.04 (0.51–2.14)], graft loss [SHR (95% CI): 1.07 (0.45–2.57)], and rejection [odds ratio(95% CI): 1.23(0.60–2.53)]. Moreover, there was no difference in immunosuppressive drug PDC in patients with and without history of psychosis/mania (PDC: 76 ± 21% vs. 78 ± 19%, P = 0.529 for tacrolimus; PDC: 78 ± 17% vs. 79 ± 18%, P = 0.666 for mycophenolic acid). After careful selection, pretransplantation psychosis/mania is not associated with adverse outcomes in kidney transplant recipients. © 2018 Steunstichting ESOT
KW - mycophenolic acid
KW - tacrolimus, adult
KW - African American
KW - age distribution
KW - all cause mortality
KW - Article
KW - Caucasian
KW - controlled study
KW - disease association
KW - female
KW - graft failure
KW - graft rejection
KW - human
KW - kidney transplantation
KW - major clinical study
KW - male
KW - mania
KW - medication compliance
KW - priority journal
KW - psychosis
KW - risk assessment
KW - risk factor
KW - sex difference
KW - treatment outcome
KW - veteran
KW - aged
KW - bipolar disorder
KW - cause of death
KW - complication
KW - middle aged
KW - mortality
KW - retrospective study, Aged
KW - Bipolar Disorder
KW - Cause of Death
KW - Female
KW - Graft Rejection
KW - Humans
KW - Kidney Transplantation
KW - Male
KW - Medication Adherence
KW - Middle Aged
KW - Psychotic Disorders
KW - Retrospective Studies
U2 - 10.1111/tri.13127
DO - 10.1111/tri.13127
M3 - Article
VL - 31
SP - 554
EP - 565
JO - Transplant International
JF - Transplant International
SN - 0934-0874
IS - 5
ER -