HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohort

Syed Hani Abidi, Aniqa Shahid, Laila S. Lakhani, Reena Shah, Nancy Okinda, Peter Ojwang, Farhat Abbas, Sarah Rowland-Jones, Syed Ali

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection progression markers (i.e. CD4 cell counts and viral loads) and their association with HIV-1 genetic variability and subtype, and patient's HLA type. HIV-1 gag genetic variability, analysed using bioinformatics tools, showed an inverse relationship with CD4 cell count whereas with viral load that relationship was direct. Certain HLA types and viral subtypes were also found to associate with patients' viral load. Associations between disease parameters and the genetic makeup of the host and virus may be crucial in determining the outcome of HIV-1 infection.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalMedical Microbiology and Immunology
Volume203
Issue number1
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Genetic variability
  • HIV
  • HLA
  • Kenya
  • Progression markers
  • Subtype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Microbiology (medical)

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