HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B virus infection and during interferon therapy in chronic hepatitis B virus infection

Massimo Pignatelli, Jenny Waters, Dave Brown, Andrew Lever, Sten Iwarson, Zsuzsa Schaff, Robert Gerety, Howard C. Thomas

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

In a chimpanzee model of acute type B hepatitis, at the time of onset of hepatitis B virus replication and before the development of immunity to hepatitis B virus, interferon is present in the plasma. This is followed by an increase in the display of HLA class I, but not class II proteins, on the hepatocyte membrane. In chronic hepatitis B virus infection, there is a low density of HLA class I protein display on the infected hepatocyte. Administration of α‐interferon enhances HLA display and in many cases is followed by a transaminase elevation, seroconversion of HBe antigen to antibody and disappearance of hepatitis B virus DNA from serum, changes implying clearance of infected hepatocytes. Successful response to interferon therapy may be predicted by a rapidly rising serum β‐microglobulin, a component of the HLA class I molecule, during the first 2 weeks of therapy, before the rise in transaminases.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalHepatology
Volume6
Issue number3
DOIs
Publication statusPublished - Jan 1 1986

ASJC Scopus subject areas

  • Hepatology

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