HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B virus infection and during interferon therapy in chronic hepatitis B virus infection

M. Pignatelli, J. Waters, A. Brown, A. Lever, S. Iwarson, Z. Schaff, R. Gerety, H. C. Thomas

Research output: Contribution to journalArticle

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Abstract

In a chimpanzee model of acute type B hepatitis, at the time of onset of hepatitis B virus replication and before the development of immunity to hepatitis B virus, interferon is present in the plasma. This is followed by an increase in the display of HLA class I, but not class II proteins, on the hepatocyte membrane. In chronic hepatitis B virus infection, there is a low density of HLA class I protein display on the infected hepatocyte. Administration of α-interferon enhances HLA display and in many cases is followed by a transaminase elevation, seroconversion of HBe antigen to antibody and disappearance of hepatitis B virus DNA from serum, changes implying clearance of infected hepatocytes. Successful response to interferon therapy may be predicted by a rapidly rising serum β2-microglobulin, a component of the HLA class I molecule, during the first 2 weeks of therapy, before the rise in transaminases.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalHepatology
Volume6
Issue number3
Publication statusPublished - 1986
Externally publishedYes

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Histocompatibility Antigens Class I
Chronic Hepatitis B
Virus Diseases
HLA Antigens
Hepatitis B virus
Interferons
Hepatocytes
Transaminases
Membranes
Hepatitis B Antibodies
Pan troglodytes
Virus Replication
Hepatitis B
Serum
Immunity
Proteins
Therapeutics
Antigens
DNA

ASJC Scopus subject areas

  • Hepatology

Cite this

HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B virus infection and during interferon therapy in chronic hepatitis B virus infection. / Pignatelli, M.; Waters, J.; Brown, A.; Lever, A.; Iwarson, S.; Schaff, Z.; Gerety, R.; Thomas, H. C.

In: Hepatology, Vol. 6, No. 3, 1986, p. 349-353.

Research output: Contribution to journalArticle

Pignatelli, M. ; Waters, J. ; Brown, A. ; Lever, A. ; Iwarson, S. ; Schaff, Z. ; Gerety, R. ; Thomas, H. C. / HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B virus infection and during interferon therapy in chronic hepatitis B virus infection. In: Hepatology. 1986 ; Vol. 6, No. 3. pp. 349-353.
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