Abstract
In a chimpanzee model of acute type B hepatitis, at the time of onset of hepatitis B virus replication and before the development of immunity to hepatitis B virus, interferon is present in the plasma. This is followed by an increase in the display of HLA class I, but not class II proteins, on the hepatocyte membrane. In chronic hepatitis B virus infection, there is a low density of HLA class I protein display on the infected hepatocyte. Administration of α-interferon enhances HLA display and in many cases is followed by a transaminase elevation, seroconversion of HBe antigen to antibody and disappearance of hepatitis B virus DNA from serum, changes implying clearance of infected hepatocytes. Successful response to interferon therapy may be predicted by a rapidly rising serum β2-microglobulin, a component of the HLA class I molecule, during the first 2 weeks of therapy, before the rise in transaminases.
| Original language | English |
|---|---|
| Pages (from-to) | 349-353 |
| Number of pages | 5 |
| Journal | Hepatology |
| Volume | 6 |
| Issue number | 3 |
| Publication status | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Hepatology
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HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B virus infection and during interferon therapy in chronic hepatitis B virus infection. / Pignatelli, M.; Waters, J.; Brown, A.; Lever, A.; Iwarson, S.; Schaff, Z.; Gerety, R.; Thomas, H. C.
In: Hepatology, Vol. 6, No. 3, 1986, p. 349-353.Research output: Contribution to journal › Article
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TY - JOUR
T1 - HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B virus infection and during interferon therapy in chronic hepatitis B virus infection
AU - Pignatelli, M.
AU - Waters, J.
AU - Brown, A.
AU - Lever, A.
AU - Iwarson, S.
AU - Schaff, Z.
AU - Gerety, R.
AU - Thomas, H. C.
PY - 1986
Y1 - 1986
N2 - In a chimpanzee model of acute type B hepatitis, at the time of onset of hepatitis B virus replication and before the development of immunity to hepatitis B virus, interferon is present in the plasma. This is followed by an increase in the display of HLA class I, but not class II proteins, on the hepatocyte membrane. In chronic hepatitis B virus infection, there is a low density of HLA class I protein display on the infected hepatocyte. Administration of α-interferon enhances HLA display and in many cases is followed by a transaminase elevation, seroconversion of HBe antigen to antibody and disappearance of hepatitis B virus DNA from serum, changes implying clearance of infected hepatocytes. Successful response to interferon therapy may be predicted by a rapidly rising serum β2-microglobulin, a component of the HLA class I molecule, during the first 2 weeks of therapy, before the rise in transaminases.
AB - In a chimpanzee model of acute type B hepatitis, at the time of onset of hepatitis B virus replication and before the development of immunity to hepatitis B virus, interferon is present in the plasma. This is followed by an increase in the display of HLA class I, but not class II proteins, on the hepatocyte membrane. In chronic hepatitis B virus infection, there is a low density of HLA class I protein display on the infected hepatocyte. Administration of α-interferon enhances HLA display and in many cases is followed by a transaminase elevation, seroconversion of HBe antigen to antibody and disappearance of hepatitis B virus DNA from serum, changes implying clearance of infected hepatocytes. Successful response to interferon therapy may be predicted by a rapidly rising serum β2-microglobulin, a component of the HLA class I molecule, during the first 2 weeks of therapy, before the rise in transaminases.
UR - http://www.scopus.com/inward/record.url?scp=0022471033&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022471033&partnerID=8YFLogxK
M3 - Article
C2 - 2423427
AN - SCOPUS:0022471033
VL - 6
SP - 349
EP - 353
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 3
ER -