Homeogene expression patterns and chromosomal imprinting

S J Gaunt, P B Singh

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

In both mouse and Drosophila, Antennapedia-like homeobox-containing genes (homeogenes) display a strict correspondence between the order of genes (3' to 5') along the chromosome and the order of their expression domains (anterior to posterior) in the developing embryo. We show here how this, and other points of similarity, may indicate that both species use a common mechanism of chromosomal imprinting in order to retain cellular memory of homeogene expression patterns throughout embryonic development.

Original languageEnglish
Pages (from-to)208-12
Number of pages5
JournalTrends in Genetics
Volume6
Issue number7
Publication statusPublished - Jul 1990

Fingerprint

Homeobox Genes
Chromosomes, Human, Pair 5
Gene Order
Drosophila
Embryonic Development
Embryonic Structures
Gene Expression
Imprinting (Psychology)

Keywords

  • Animals
  • Chromosomes
  • Drosophila melanogaster
  • Embryonic and Fetal Development
  • Gene Expression
  • Genes, Homeobox
  • Mice
  • Models, Genetic
  • Journal Article
  • Review

Cite this

Homeogene expression patterns and chromosomal imprinting. / Gaunt, S J; Singh, P B.

In: Trends in Genetics, Vol. 6, No. 7, 07.1990, p. 208-12.

Research output: Contribution to journalReview article

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KW - Animals

KW - Chromosomes

KW - Drosophila melanogaster

KW - Embryonic and Fetal Development

KW - Gene Expression

KW - Genes, Homeobox

KW - Mice

KW - Models, Genetic

KW - Journal Article

KW - Review

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