Homeogene expression patterns and chromosomal imprinting

S J Gaunt, P B Singh

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

In both mouse and Drosophila, Antennapedia-like homeobox-containing genes (homeogenes) display a strict correspondence between the order of genes (3' to 5') along the chromosome and the order of their expression domains (anterior to posterior) in the developing embryo. We show here how this, and other points of similarity, may indicate that both species use a common mechanism of chromosomal imprinting in order to retain cellular memory of homeogene expression patterns throughout embryonic development.

Original languageEnglish
Pages (from-to)208-12
Number of pages5
JournalTrends in Genetics
Volume6
Issue number7
Publication statusPublished - Jul 1990

Keywords

  • Animals
  • Chromosomes
  • Drosophila melanogaster
  • Embryonic and Fetal Development
  • Gene Expression
  • Genes, Homeobox
  • Mice
  • Models, Genetic
  • Journal Article
  • Review

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    Gaunt, S. J., & Singh, P. B. (1990). Homeogene expression patterns and chromosomal imprinting. Trends in Genetics, 6(7), 208-12.