Homeogene expression patterns and chromosomal imprinting

S J Gaunt, P B Singh

Research output: Contribution to journalReview articlepeer-review

86 Citations (Scopus)


In both mouse and Drosophila, Antennapedia-like homeobox-containing genes (homeogenes) display a strict correspondence between the order of genes (3' to 5') along the chromosome and the order of their expression domains (anterior to posterior) in the developing embryo. We show here how this, and other points of similarity, may indicate that both species use a common mechanism of chromosomal imprinting in order to retain cellular memory of homeogene expression patterns throughout embryonic development.

Original languageEnglish
Pages (from-to)208-12
Number of pages5
JournalTrends in Genetics
Issue number7
Publication statusPublished - Jul 1990


  • Animals
  • Chromosomes
  • Drosophila melanogaster
  • Embryonic and Fetal Development
  • Gene Expression
  • Genes, Homeobox
  • Mice
  • Models, Genetic
  • Journal Article
  • Review

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