TY - JOUR
T1 - Homopiperazine Pt(II) adducts with DNA bases and nucleosides
T2 - Crystal structure of [PtII(homopiperazine)(9-ethylguanine)2](NO3)2
AU - Ali, Mohammad S.
AU - Longoria, Edio
AU - Ely, Teyeb Ould
AU - Whitmire, Kenton H.
AU - Khokhar, Abdul R.
N1 - Funding Information:
This work was supported in part by Grant C-0976 from The Robert Welch Foundation.
PY - 2006/7/10
Y1 - 2006/7/10
N2 - A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.
AB - A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.
KW - Adducts
KW - Crystal structure
KW - Nucleobase
KW - Nucleoside
KW - Platinum
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U2 - 10.1016/j.poly.2006.01.003
DO - 10.1016/j.poly.2006.01.003
M3 - Article
AN - SCOPUS:33744799151
VL - 25
SP - 2065
EP - 2071
JO - Polyhedron
JF - Polyhedron
SN - 0277-5387
IS - 10
ER -