Homopiperazine Pt(II) adducts with DNA bases and nucleosides

Crystal structure of [PtII(homopiperazine)(9-ethylguanine)2](NO3)2

Mohammad S. Ali, Edio Longoria, Teyeb Ould Ely, Kenton H. Whitmire, Abdul R. Khokhar

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.

Original languageEnglish
Pages (from-to)2065-2071
Number of pages7
JournalPolyhedron
Volume25
Issue number10
DOIs
Publication statusPublished - Jul 10 2006
Externally publishedYes

Fingerprint

nucleosides
DNA Adducts
Nucleosides
adducts
Platinum
platinum
DNA
deoxyribonucleic acid
Crystal structure
crystal structure
Nitrogen
adenines
magnetic resonance spectroscopy
Cytidine
nitrogen atoms
Nuclear magnetic resonance spectroscopy
Cytosine
Adenine
X-Ray Diffraction
Ligands

Keywords

  • Adducts
  • Crystal structure
  • Nucleobase
  • Nucleoside
  • Platinum

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Homopiperazine Pt(II) adducts with DNA bases and nucleosides : Crystal structure of [PtII(homopiperazine)(9-ethylguanine)2](NO3)2. / Ali, Mohammad S.; Longoria, Edio; Ely, Teyeb Ould; Whitmire, Kenton H.; Khokhar, Abdul R.

In: Polyhedron, Vol. 25, No. 10, 10.07.2006, p. 2065-2071.

Research output: Contribution to journalArticle

Ali, Mohammad S. ; Longoria, Edio ; Ely, Teyeb Ould ; Whitmire, Kenton H. ; Khokhar, Abdul R. / Homopiperazine Pt(II) adducts with DNA bases and nucleosides : Crystal structure of [PtII(homopiperazine)(9-ethylguanine)2](NO3)2. In: Polyhedron. 2006 ; Vol. 25, No. 10. pp. 2065-2071.
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