Homopiperazine Pt(II) adducts with DNA bases and nucleosides: Crystal structure of [PtII(homopiperazine)(9-ethylguanine)2](NO3)2

Mohammad S. Ali, Edio Longoria, Teyeb Ould Ely, Kenton H. Whitmire, Abdul R. Khokhar

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12 Citations (Scopus)

Abstract

A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.

Original languageEnglish
Pages (from-to)2065-2071
Number of pages7
JournalPolyhedron
Volume25
Issue number10
DOIs
Publication statusPublished - Jul 10 2006

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Keywords

  • Adducts
  • Crystal structure
  • Nucleobase
  • Nucleoside
  • Platinum

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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