Homopiperazine Pt(II) adducts with DNA bases and nucleosides: Crystal structure of [PtII(homopiperazine)(9-ethylguanine)2](NO3)2

Mohammad S. Ali; Edio Longoria; Teyeb Ould Ely; Kenton H. Whitmire; Abdul R. Khokhar

doi:10.1016/j.poly.2006.01.003

Homopiperazine Pt(II) adducts with DNA bases and nucleosides: Crystal structure of [Pt^II(homopiperazine)(9-ethylguanine)₂](NO₃)₂

Mohammad S. Ali, Edio Longoria, Teyeb Ould Ely, Kenton H. Whitmire, Abdul R. Khokhar

Department of Chemistry

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

A series of platinum(II) mono- and diadducts of the type [Pt^II(hmp)XCl]NO₃ and [Pt^II(hmp)X₂](NO₃)₂ (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by ¹H, ¹³C, and ¹⁹⁵Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [Pt^II(homopiperazine)(9-ethylguanine)₂](NO₃)₂ was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C₂ molecular symmetry.

Original language	English
Pages (from-to)	2065-2071
Number of pages	7
Journal	Polyhedron
Volume	25
Issue number	10
DOIs	https://doi.org/10.1016/j.poly.2006.01.003
Publication status	Published - Jul 10 2006

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Keywords

Adducts
Crystal structure
Nucleobase
Nucleoside
Platinum

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Cite this

Ali, M. S., Longoria, E., Ely, T. O., Whitmire, K. H., & Khokhar, A. R. (2006). Homopiperazine Pt(II) adducts with DNA bases and nucleosides: Crystal structure of [Pt^II(homopiperazine)(9-ethylguanine)₂](NO₃)₂. Polyhedron, 25(10), 2065-2071. https://doi.org/10.1016/j.poly.2006.01.003

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abstract = "A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.",

keywords = "Adducts, Crystal structure, Nucleobase, Nucleoside, Platinum",

author = "Ali, {Mohammad S.} and Edio Longoria and Ely, {Teyeb Ould} and Whitmire, {Kenton H.} and Khokhar, {Abdul R.}",

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AU - Longoria, Edio

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AU - Whitmire, Kenton H.

AU - Khokhar, Abdul R.

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N2 - A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.

AB - A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.

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10.1016/j.poly.2006.01.003