Abstract
A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.
| Original language | English |
|---|---|
| Pages (from-to) | 2065-2071 |
| Number of pages | 7 |
| Journal | Polyhedron |
| Volume | 25 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Jul 10 2006 |
| Externally published | Yes |
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Keywords
- Adducts
- Crystal structure
- Nucleobase
- Nucleoside
- Platinum
ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry
- Physical and Theoretical Chemistry
- Materials Chemistry
Cite this
Homopiperazine Pt(II) adducts with DNA bases and nucleosides : Crystal structure of [PtII(homopiperazine)(9-ethylguanine)2](NO3)2. / Ali, Mohammad S.; Longoria, Edio; Ely, Teyeb Ould; Whitmire, Kenton H.; Khokhar, Abdul R.
In: Polyhedron, Vol. 25, No. 10, 10.07.2006, p. 2065-2071.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Homopiperazine Pt(II) adducts with DNA bases and nucleosides
T2 - Crystal structure of [PtII(homopiperazine)(9-ethylguanine)2](NO3)2
AU - Ali, Mohammad S.
AU - Longoria, Edio
AU - Ely, Teyeb Ould
AU - Whitmire, Kenton H.
AU - Khokhar, Abdul R.
PY - 2006/7/10
Y1 - 2006/7/10
N2 - A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.
AB - A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry.
KW - Adducts
KW - Crystal structure
KW - Nucleobase
KW - Nucleoside
KW - Platinum
UR - http://www.scopus.com/inward/record.url?scp=33744799151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33744799151&partnerID=8YFLogxK
U2 - 10.1016/j.poly.2006.01.003
DO - 10.1016/j.poly.2006.01.003
M3 - Article
VL - 25
SP - 2065
EP - 2071
JO - Polyhedron
JF - Polyhedron
SN - 0277-5387
IS - 10
ER -