HP1

facts, open questions, and speculation

Prim B Singh, Spyros D Georgatos

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

The demonstration, over a decade ago, that HP1 is a highly conserved constituent of heterochromatin was accompanied by the explicit view that this protein plays a pivotal role in epigenetic regulation (P.B. Singh, J.R. Miller, J. Pearce, R. Kothary, R.D. Burton, R. Paro, T.C. James, and S.J. Gaunt, 1991, Nucleic Acids Res. 19, 789-794). Recent studies have confirmed this view, unveiling specific interactions of HP1 with a variety of histone and nonhistone proteins. We discuss here some of these observations, concentrating on structure-function relationships and intracellular dynamics. Integrating the available information, we also present a hypothetical model describing how HP1, acting as a bifunctional cross-linker, could organize peripheral heterochromatin and contribute in the compartmentalization of the cell nucleus.

Original languageEnglish
Pages (from-to)10-6
Number of pages7
JournalJournal of Structural Biology
Volume140
Issue number1-3
Publication statusPublished - Dec 20 2002
Externally publishedYes

Fingerprint

Heterochromatin
Cell Nucleus
Epigenomics
Histones
Nucleic Acids
Proteins

Keywords

  • Animals
  • Chromosomal Proteins, Non-Histone
  • Circular Dichroism
  • Dimerization
  • Drosophila Proteins
  • Drosophila melanogaster
  • Heterochromatin
  • Histones
  • Models, Molecular
  • Nuclear Envelope
  • Peptides
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Cite this

HP1 : facts, open questions, and speculation. / Singh, Prim B; Georgatos, Spyros D.

In: Journal of Structural Biology, Vol. 140, No. 1-3, 20.12.2002, p. 10-6.

Research output: Contribution to journalReview article

Singh, PB & Georgatos, SD 2002, 'HP1: facts, open questions, and speculation', Journal of Structural Biology, vol. 140, no. 1-3, pp. 10-6.
Singh, Prim B ; Georgatos, Spyros D. / HP1 : facts, open questions, and speculation. In: Journal of Structural Biology. 2002 ; Vol. 140, No. 1-3. pp. 10-6.
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