HP1: facts, open questions, and speculation

Prim B Singh, Spyros D Georgatos

Research output: Contribution to journalReview articlepeer-review

62 Citations (Scopus)


The demonstration, over a decade ago, that HP1 is a highly conserved constituent of heterochromatin was accompanied by the explicit view that this protein plays a pivotal role in epigenetic regulation (P.B. Singh, J.R. Miller, J. Pearce, R. Kothary, R.D. Burton, R. Paro, T.C. James, and S.J. Gaunt, 1991, Nucleic Acids Res. 19, 789-794). Recent studies have confirmed this view, unveiling specific interactions of HP1 with a variety of histone and nonhistone proteins. We discuss here some of these observations, concentrating on structure-function relationships and intracellular dynamics. Integrating the available information, we also present a hypothetical model describing how HP1, acting as a bifunctional cross-linker, could organize peripheral heterochromatin and contribute in the compartmentalization of the cell nucleus.

Original languageEnglish
Pages (from-to)10-6
Number of pages7
JournalJournal of Structural Biology
Issue number1-3
Publication statusPublished - Dec 20 2002
Externally publishedYes


  • Animals
  • Chromosomal Proteins, Non-Histone
  • Circular Dichroism
  • Dimerization
  • Drosophila Proteins
  • Drosophila melanogaster
  • Heterochromatin
  • Histones
  • Models, Molecular
  • Nuclear Envelope
  • Peptides
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review


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