Hypermethylation of human calcitonin gene in leukemias of myeloid origin

D. V. Marinich, I. A. Vorobyev, V. V. Smolnikova, J. Holms, D. Baban, T. V. Shevchuk, Ya I. Buryanov, A. I. Miroshnikov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The inner cytosine methylation in site CCGG of the human calcitonin gene was revealed in the DNA samples obtained from peripheral blood and bone marrow of patients with acute myeloid leukemia, myelodysplastic syndrome and also from patients with chronic myeloid leukemia in blast crisis phase. It is shown that the CCGG site's methylation of this area is a characteristic property of tumor progression in leukemias of myeloid origin. The calcitonin gene methylation state might be a diagnostic marker in monitoring of myeloid disorders.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalGematologiya i Transfusiologiya
Volume44
Issue number4
Publication statusPublished - Dec 1 1999

Keywords

  • Acute myelogenous leukemia
  • Calcitonin gene
  • Chronic myelogenous leukemia
  • DNA methylation
  • Diagnosis
  • Myelodisplastic syndrome

ASJC Scopus subject areas

  • Hematology

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