Hypermethylation of human calcitonin gene in leukemias of myeloid origin

D. V. Marinich; I. A. Vorobyev; V. V. Smolnikova; J. Holms; D. Baban; T. V. Shevchuk; Ya I. Buryanov; A. I. Miroshnikov

Hypermethylation of human calcitonin gene in leukemias of myeloid origin

D. V. Marinich, I. A. Vorobyev, V. V. Smolnikova, J. Holms, D. Baban, T. V. Shevchuk, Ya I. Buryanov, A. I. Miroshnikov

Department of Biology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The inner cytosine methylation in site CCGG of the human calcitonin gene was revealed in the DNA samples obtained from peripheral blood and bone marrow of patients with acute myeloid leukemia, myelodysplastic syndrome and also from patients with chronic myeloid leukemia in blast crisis phase. It is shown that the CCGG site's methylation of this area is a characteristic property of tumor progression in leukemias of myeloid origin. The calcitonin gene methylation state might be a diagnostic marker in monitoring of myeloid disorders.

Original language	English
Pages (from-to)	7-10
Number of pages	4
Journal	Gematologiya i Transfusiologiya
Volume	44
Issue number	4
Publication status	Published - Dec 1 1999

Keywords

Acute myelogenous leukemia
Calcitonin gene
Chronic myelogenous leukemia
DNA methylation
Diagnosis
Myelodisplastic syndrome

ASJC Scopus subject areas

Hematology

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title = "Hypermethylation of human calcitonin gene in leukemias of myeloid origin",

abstract = "The inner cytosine methylation in site CCGG of the human calcitonin gene was revealed in the DNA samples obtained from peripheral blood and bone marrow of patients with acute myeloid leukemia, myelodysplastic syndrome and also from patients with chronic myeloid leukemia in blast crisis phase. It is shown that the CCGG site's methylation of this area is a characteristic property of tumor progression in leukemias of myeloid origin. The calcitonin gene methylation state might be a diagnostic marker in monitoring of myeloid disorders.",

keywords = "Acute myelogenous leukemia, Calcitonin gene, Chronic myelogenous leukemia, DNA methylation, Diagnosis, Myelodisplastic syndrome",

author = "Marinich, {D. V.} and Vorobyev, {I. A.} and Smolnikova, {V. V.} and J. Holms and D. Baban and Shevchuk, {T. V.} and Buryanov, {Ya I.} and Miroshnikov, {A. I.}",

year = "1999",

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T1 - Hypermethylation of human calcitonin gene in leukemias of myeloid origin

AU - Marinich, D. V.

AU - Vorobyev, I. A.

AU - Smolnikova, V. V.

AU - Holms, J.

AU - Baban, D.

AU - Shevchuk, T. V.

AU - Buryanov, Ya I.

AU - Miroshnikov, A. I.

PY - 1999/12/1

Y1 - 1999/12/1

N2 - The inner cytosine methylation in site CCGG of the human calcitonin gene was revealed in the DNA samples obtained from peripheral blood and bone marrow of patients with acute myeloid leukemia, myelodysplastic syndrome and also from patients with chronic myeloid leukemia in blast crisis phase. It is shown that the CCGG site's methylation of this area is a characteristic property of tumor progression in leukemias of myeloid origin. The calcitonin gene methylation state might be a diagnostic marker in monitoring of myeloid disorders.

AB - The inner cytosine methylation in site CCGG of the human calcitonin gene was revealed in the DNA samples obtained from peripheral blood and bone marrow of patients with acute myeloid leukemia, myelodysplastic syndrome and also from patients with chronic myeloid leukemia in blast crisis phase. It is shown that the CCGG site's methylation of this area is a characteristic property of tumor progression in leukemias of myeloid origin. The calcitonin gene methylation state might be a diagnostic marker in monitoring of myeloid disorders.

KW - Acute myelogenous leukemia

KW - Calcitonin gene

KW - Chronic myelogenous leukemia

KW - DNA methylation

KW - Diagnosis

KW - Myelodisplastic syndrome

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