Identification of parathyroid hormone inhibiting bioactivity of the human fetal and neonatal thymus: Preliminary communication

M. Jevremovic, M. Arambasic, A. Piroskov, M. Terzic, M. Pesic

Research output: Contribution to journalArticlepeer-review

Abstract

The parathyroid hormone (PTH) is important for the calcium balance in humans. It apparently participates in the development of osteoporosis, especially in the senile type (Type II). This study investigates the parathyroid hormone inhibitory bioactivity of the human fetal and neonatal thymus. The PTH inhibiting bioactivity was determined in the human fetal and neonatal thymus glands specimen (HTE - human fetal thymus extract) obtained in post mortem autopsies immediately after spontaneous abortion or delivery. PTH was evaluated by quantitative bioassay on experimental animals (36 rats) after the administration of HTE and PTH standard (Bachem). The obtained data suggest thatt the thymic gland possesses an antiparathyroid inhibitory bioactivity.

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalInternational Journal of Thymology
Volume3
Issue number6
Publication statusPublished - Dec 1 1995
Externally publishedYes

Keywords

  • antiparathyroid effect
  • parathyroid hormone
  • thymus

ASJC Scopus subject areas

  • Immunology
  • Endocrinology

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