Immune Cells and Immunosenescence

J. Bischof, F. Gärtner, K. Zeiser, R. Kunz, C. Schreiner, E. Hoffer, T. Burster, U. Knippschild, M. Zimecki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Aging is associated with progressive loss of physiological integrity, leading to impaired physical and mental functions as well as increased morbidity and mortality. With advancing age, the immune system is no longer able to adequately control autoimmunity, infections, or cancer. The abilities of the elderly to slow down undesirable effects of aging may depend on the genetic background, lifestyle, geographic region, and other presently unknown factors. Although most aspects of the immunity are constantly declining in relation to age, some features are retained, while e.g. the ability to produce high levels of cytokines, response to pathogens by increased inflammation, and imbalanced proteolytic activity are found in the elderly, and might eventually cause harm. In this context, it is important to differentiate between the effect of immunosenescence that is contributing to this decline and adaptations of the immune system that can be quickly reversed if necessary.

Original languageEnglish
Pages (from-to)53-63
Number of pages11
JournalFolia Biologica
Volume65
Issue number2
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Molecular Biology
  • Genetics
  • Developmental Biology
  • Cell Biology

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