Immune phenotypes predict survival in patients with glioblastoma multiforme

Haouraa Mostafa, Andrej Pala, Josef Högel, Michal Hlavac, Elvira Dietrich, M Andrew Westhoff, Lisa Nonnenmacher, Timo Burster, Michael Georgieff, C Rainer Wirtz, E Marion Schneider

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

BACKGROUND: Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of immunological control in individual patients with GBM.

METHODS: Immune phenotypes and plasma biomarkers of GBM patients were determined at the time of diagnosis using flow cytometry and ELISA, respectively.

RESULTS: Using descriptive statistics, we found that immune anomalies were distinct in individual patients. Defined marker profiles proved highly relevant for survival. A remarkable relation between activated NK cells and improved survival in GBM patients was in contrast to increased CD39 and IL-10 in patients with a detrimental course and very short survival. Recursive partitioning analysis (RPA) and Cox proportional hazards models substantiated the relevance of absolute numbers of CD8 cells and low numbers of CD39 cells for better survival.

CONCLUSIONS: Defined alterations of the immune system may guide the course of disease in patients with GBM and may be prognostically valuable for longitudinal studies or can be applied for immune intervention.

Original languageEnglish
Pages (from-to)77
JournalJournal of Hematology and Oncology
Volume9
Issue number1
DOIs
Publication statusPublished - Sep 1 2016
Externally publishedYes

Fingerprint

Glioblastoma
Phenotype
Survival
Cell Survival
Proportional Hazards Models
Brain Neoplasms
Natural Killer Cells
Interleukin-10
Longitudinal Studies
Immune System
Flow Cytometry
Central Nervous System
Cell Count
Biomarkers
Enzyme-Linked Immunosorbent Assay

Keywords

  • Adult
  • Aged
  • Antigens, CD
  • Apyrase
  • Biomarkers
  • Female
  • Glioblastoma
  • Humans
  • Immunophenotyping
  • Interleukin-10
  • Killer Cells, Natural
  • Male
  • Middle Aged
  • Prognosis
  • Survival Analysis
  • Young Adult
  • Journal Article

Cite this

Mostafa, H., Pala, A., Högel, J., Hlavac, M., Dietrich, E., Westhoff, M. A., ... Schneider, E. M. (2016). Immune phenotypes predict survival in patients with glioblastoma multiforme. Journal of Hematology and Oncology, 9(1), 77. https://doi.org/10.1186/s13045-016-0272-3

Immune phenotypes predict survival in patients with glioblastoma multiforme. / Mostafa, Haouraa; Pala, Andrej; Högel, Josef; Hlavac, Michal; Dietrich, Elvira; Westhoff, M Andrew; Nonnenmacher, Lisa; Burster, Timo; Georgieff, Michael; Wirtz, C Rainer; Schneider, E Marion.

In: Journal of Hematology and Oncology, Vol. 9, No. 1, 01.09.2016, p. 77.

Research output: Contribution to journalArticle

Mostafa, H, Pala, A, Högel, J, Hlavac, M, Dietrich, E, Westhoff, MA, Nonnenmacher, L, Burster, T, Georgieff, M, Wirtz, CR & Schneider, EM 2016, 'Immune phenotypes predict survival in patients with glioblastoma multiforme', Journal of Hematology and Oncology, vol. 9, no. 1, pp. 77. https://doi.org/10.1186/s13045-016-0272-3
Mostafa, Haouraa ; Pala, Andrej ; Högel, Josef ; Hlavac, Michal ; Dietrich, Elvira ; Westhoff, M Andrew ; Nonnenmacher, Lisa ; Burster, Timo ; Georgieff, Michael ; Wirtz, C Rainer ; Schneider, E Marion. / Immune phenotypes predict survival in patients with glioblastoma multiforme. In: Journal of Hematology and Oncology. 2016 ; Vol. 9, No. 1. pp. 77.
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