IMMUNOCYTOCHEMICAL LOCALIZATION OF THE TERMINAL COMPLEMENT COMPLEX IN MULTIPLE SCLEROSIS

D. A.S. COMPSTON, B. P. MORGAN, A. K. CAMPBELL, P. WILKINS, G. COLE, N. D. THOMAS, B. JASANI

Research output: Contribution to journalArticlepeer-review

159 Citations (Scopus)

Abstract

Granular deposits of C9 and the terminal complement complex, measuring 0–3–1 2 μm, have been demonstrated immunocytochemically in association with capillary endothelial cells, predominantly within plaques and adjacent white matter, in tissue obtained at autopsy from 5/7 patients with multiple sclerosis (MS) and one individual with subacute sclerosing panencephalitis but not from 7/7 controls. This finding suggests that the evolution of focal tissue damage in MS may involve complement activation associated with passage of humoral and cellular mediators of the immune system through the blood–brain barrier.

Original languageEnglish
Pages (from-to)307-316
Number of pages10
JournalNeuropathology and Applied Neurobiology
Volume15
Issue number4
DOIs
Publication statusPublished - Aug 1989

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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