Immunocytochemically detectable TGF-β associated with malignancy in thyroid epithelial neoplasia

B. Jasani, F. S. Wyllie, P. A. Wright, N. R. Lemoine, E. D. Williams, D. Wynford-Thomas

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

The possible role of changes in TGF-β expression in the multistage development of thyroid cancer was assessed. The presence of TGF-β1 in thyroid epithelial cells was analyzed in sections of normal and tumor tissue using an immunoperoxidase technique employing an antibody directed against the amino-terminal 30 amino acids of mature TGF-β1. Specific immunostaining was clearly detected in epithelial cells in 58% of malignant thyroid tumours (including follicular, papillary, and anaplastic variants). However, no positive cells were seen in any of 7 benign tumors nor in any normal thyroid epithelium. Within the cancer group as a whole, there was no significant correlation with pathological grade or clinical stage of tumor but in one subgroup-follicular carcinomas-a significant association was noted between TGF-β immunostaining and the presence of a specific mutation of the H-ras oncogene (codon 61, glnarg). We conclude that a major alteration in expression of TGF-β occurs specifically in the malignant stage of tumor development in thyroid follicular epithelium and speculate on its possible role in this process.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalGrowth Factors
Volume2
Issue number2
DOIs
Publication statusPublished - Jan 1 1990

Keywords

  • Cancer
  • Epithelial cells
  • TGF-β
  • Thyroid

ASJC Scopus subject areas

  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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