Immunocytochemically detectable TGF-β associated with malignancy in thyroid epithelial neoplasia

B. Jasani, F. S. Wyllie, P. A. Wright, N. R. Lemoine, E. D. Williams, D. Wynford-Thomas

Research output: Contribution to journalArticle

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Abstract

The possible role of changes in TGF-β expression in the multistage development of thyroid cancer was assessed. The presence of TGF-β1 in thyroid epithelial cells was analyzed in sections of normal and tumor tissue using an immunoperoxidase technique employing an antibody directed against the amino-terminal 30 amino acids of mature TGF-β1. Specific immunostaining was clearly detected in epithelial cells in 58% of malignant thyroid tumours (including follicular, papillary, and anaplastic variants). However, no positive cells were seen in any of 7 benign tumors nor in any normal thyroid epithelium. Within the cancer group as a whole, there was no significant correlation with pathological grade or clinical stage of tumor but in one subgroup-follicular carcinomas-a significant association was noted between TGF-β immunostaining and the presence of a specific mutation of the H-ras oncogene (codon 61, glnarg). We conclude that a major alteration in expression of TGF-β occurs specifically in the malignant stage of tumor development in thyroid follicular epithelium and speculate on its possible role in this process.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalGrowth Factors
Volume2
Issue number2
DOIs
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Tumors
Thyroid Gland
Neoplasms
Epithelium
ras Genes
Immunoenzyme Techniques
Thyroid Neoplasms
Codon
Cells
Tissue
Amino Acids
Epithelial Cells
Antibodies
Carcinoma
Mutation

Keywords

  • Cancer
  • Epithelial cells
  • TGF-β
  • Thyroid

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology
  • Cell Biology

Cite this

Jasani, B., Wyllie, F. S., Wright, P. A., Lemoine, N. R., Williams, E. D., & Wynford-Thomas, D. (1990). Immunocytochemically detectable TGF-β associated with malignancy in thyroid epithelial neoplasia. Growth Factors, 2(2), 149-155. https://doi.org/10.3109/08977199009071501

Immunocytochemically detectable TGF-β associated with malignancy in thyroid epithelial neoplasia. / Jasani, B.; Wyllie, F. S.; Wright, P. A.; Lemoine, N. R.; Williams, E. D.; Wynford-Thomas, D.

In: Growth Factors, Vol. 2, No. 2, 1990, p. 149-155.

Research output: Contribution to journalArticle

Jasani, B, Wyllie, FS, Wright, PA, Lemoine, NR, Williams, ED & Wynford-Thomas, D 1990, 'Immunocytochemically detectable TGF-β associated with malignancy in thyroid epithelial neoplasia', Growth Factors, vol. 2, no. 2, pp. 149-155. https://doi.org/10.3109/08977199009071501
Jasani, B. ; Wyllie, F. S. ; Wright, P. A. ; Lemoine, N. R. ; Williams, E. D. ; Wynford-Thomas, D. / Immunocytochemically detectable TGF-β associated with malignancy in thyroid epithelial neoplasia. In: Growth Factors. 1990 ; Vol. 2, No. 2. pp. 149-155.
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