Immunohistochemical estimation of p53 and Bcl-2 oncoproteins expression in lymphogranulomatosis

K. D. Kaplanov, V. B. Pisarev, E. P. Korneva, I. V. Smolenov, V. A. Orlov, I. V. Gaivoronskaya, E. G. Gemdzhyan, I. A. Vorobyev

Research output: Contribution to journalArticlepeer-review

Abstract

The study of 30 patients with different variants of lymphogranulomatosis has shown that estimation of p53 and Bcl-2 proteins expression in Berezovsky-Read-Sternberg and Hodgkin's cells in combination with a detailed morphological analysis is of a significant prognostic importance. High expression of these proteins, lymphoid depletion, a reticulocellular variant, diffuse fibrosis and variants of Hodgkin's sarcoma positively correlate and, as a whole, are unfavourable prognostic signs. The absence of these three signs is prognostically favourable. However, a prognostic role of staging lymphogranulomatosis by Ann-Arbor was not confirmed.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalGematologiya i Transfusiologiya
Volume49
Issue number2
Publication statusPublished - May 24 2004

Keywords

  • Bcl-2
  • Immunochemistry
  • Lymphogranulomatosis
  • Morphology
  • Prognostic factors
  • p53

ASJC Scopus subject areas

  • Hematology

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