Immunohistochemical estimation of p53 and Bcl-2 oncoproteins expression in lymphogranulomatosis

K. D. Kaplanov, V. B. Pisarev, E. P. Korneva, I. V. Smolenov, V. A. Orlov, I. V. Gaivoronskaya, E. G. Gemdzhyan, I. A. Vorobyev

Research output: Contribution to journalArticle

Abstract

The study of 30 patients with different variants of lymphogranulomatosis has shown that estimation of p53 and Bcl-2 proteins expression in Berezovsky-Read-Sternberg and Hodgkin's cells in combination with a detailed morphological analysis is of a significant prognostic importance. High expression of these proteins, lymphoid depletion, a reticulocellular variant, diffuse fibrosis and variants of Hodgkin's sarcoma positively correlate and, as a whole, are unfavourable prognostic signs. The absence of these three signs is prognostically favourable. However, a prognostic role of staging lymphogranulomatosis by Ann-Arbor was not confirmed.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalGematologiya i Transfuziologiya
Volume49
Issue number2
Publication statusPublished - 2004
Externally publishedYes

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Oncogene Proteins
Hodgkin Disease
Sarcoma
Proteins
Fibrosis

Keywords

  • Bcl-2
  • Immunochemistry
  • Lymphogranulomatosis
  • Morphology
  • p53
  • Prognostic factors

ASJC Scopus subject areas

  • Hematology

Cite this

Kaplanov, K. D., Pisarev, V. B., Korneva, E. P., Smolenov, I. V., Orlov, V. A., Gaivoronskaya, I. V., ... Vorobyev, I. A. (2004). Immunohistochemical estimation of p53 and Bcl-2 oncoproteins expression in lymphogranulomatosis. Gematologiya i Transfuziologiya, 49(2), 3-10.

Immunohistochemical estimation of p53 and Bcl-2 oncoproteins expression in lymphogranulomatosis. / Kaplanov, K. D.; Pisarev, V. B.; Korneva, E. P.; Smolenov, I. V.; Orlov, V. A.; Gaivoronskaya, I. V.; Gemdzhyan, E. G.; Vorobyev, I. A.

In: Gematologiya i Transfuziologiya, Vol. 49, No. 2, 2004, p. 3-10.

Research output: Contribution to journalArticle

Kaplanov, KD, Pisarev, VB, Korneva, EP, Smolenov, IV, Orlov, VA, Gaivoronskaya, IV, Gemdzhyan, EG & Vorobyev, IA 2004, 'Immunohistochemical estimation of p53 and Bcl-2 oncoproteins expression in lymphogranulomatosis', Gematologiya i Transfuziologiya, vol. 49, no. 2, pp. 3-10.
Kaplanov KD, Pisarev VB, Korneva EP, Smolenov IV, Orlov VA, Gaivoronskaya IV et al. Immunohistochemical estimation of p53 and Bcl-2 oncoproteins expression in lymphogranulomatosis. Gematologiya i Transfuziologiya. 2004;49(2):3-10.
Kaplanov, K. D. ; Pisarev, V. B. ; Korneva, E. P. ; Smolenov, I. V. ; Orlov, V. A. ; Gaivoronskaya, I. V. ; Gemdzhyan, E. G. ; Vorobyev, I. A. / Immunohistochemical estimation of p53 and Bcl-2 oncoproteins expression in lymphogranulomatosis. In: Gematologiya i Transfuziologiya. 2004 ; Vol. 49, No. 2. pp. 3-10.
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