The study of 30 patients with different variants of lymphogranulomatosis has shown that estimation of p53 and Bcl-2 proteins expression in Berezovsky-Read-Sternberg and Hodgkin's cells in combination with a detailed morphological analysis is of a significant prognostic importance. High expression of these proteins, lymphoid depletion, a reticulocellular variant, diffuse fibrosis and variants of Hodgkin's sarcoma positively correlate and, as a whole, are unfavourable prognostic signs. The absence of these three signs is prognostically favourable. However, a prognostic role of staging lymphogranulomatosis by Ann-Arbor was not confirmed.
|Number of pages||8|
|Journal||Gematologiya i Transfusiologiya|
|Publication status||Published - May 24 2004|
- Prognostic factors
ASJC Scopus subject areas