Abstract
Inadequate endometrial differentiation is a cause of infertility and recurrent pregnancy loss. Diagnostic histologic dating criteria may be supplemented by the immunohistochemical identification of protein markers in late secretory endometrium. Late secretory endometrium has been shown to contain prolactin. The authors report the immunohistochemical localization of prolactin and 24K protein in late secretory endometrium using monoclonal antisera and the dinitrophenyl hapten sandwich-staining technique. The appearance of these proteins in decidualized stromal cells of late secretory endometrium may provide a more specific indicator of endometrial development and differentiation, if their late appearance or absence can be correlated with pregnancy wastage.
| Original language | English |
|---|---|
| Pages (from-to) | 643-648 |
| Number of pages | 6 |
| Journal | Fertility and Sterility |
| Volume | 45 |
| Issue number | 5 |
| Publication status | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Immunohistochemical identification of prolactin and 24K protein in secretory endometrium. / McRae, M. A.; Newman, G. R.; Walker, S. M.; Jasani, B.
In: Fertility and Sterility, Vol. 45, No. 5, 1986, p. 643-648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical identification of prolactin and 24K protein in secretory endometrium
AU - McRae, M. A.
AU - Newman, G. R.
AU - Walker, S. M.
AU - Jasani, B.
PY - 1986
Y1 - 1986
N2 - Inadequate endometrial differentiation is a cause of infertility and recurrent pregnancy loss. Diagnostic histologic dating criteria may be supplemented by the immunohistochemical identification of protein markers in late secretory endometrium. Late secretory endometrium has been shown to contain prolactin. The authors report the immunohistochemical localization of prolactin and 24K protein in late secretory endometrium using monoclonal antisera and the dinitrophenyl hapten sandwich-staining technique. The appearance of these proteins in decidualized stromal cells of late secretory endometrium may provide a more specific indicator of endometrial development and differentiation, if their late appearance or absence can be correlated with pregnancy wastage.
AB - Inadequate endometrial differentiation is a cause of infertility and recurrent pregnancy loss. Diagnostic histologic dating criteria may be supplemented by the immunohistochemical identification of protein markers in late secretory endometrium. Late secretory endometrium has been shown to contain prolactin. The authors report the immunohistochemical localization of prolactin and 24K protein in late secretory endometrium using monoclonal antisera and the dinitrophenyl hapten sandwich-staining technique. The appearance of these proteins in decidualized stromal cells of late secretory endometrium may provide a more specific indicator of endometrial development and differentiation, if their late appearance or absence can be correlated with pregnancy wastage.
UR - http://www.scopus.com/inward/record.url?scp=0022575912&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022575912&partnerID=8YFLogxK
M3 - Article
C2 - 2422062
AN - SCOPUS:0022575912
VL - 45
SP - 643
EP - 648
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 5
ER -