Immunohistochemical identification of prolactin and 24K protein in secretory endometrium

M. A. McRae, G. R. Newman, S. M. Walker, B. Jasani

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Inadequate endometrial differentiation is a cause of infertility and recurrent pregnancy loss. Diagnostic histologic dating criteria may be supplemented by the immunohistochemical identification of protein markers in late secretory endometrium. Late secretory endometrium has been shown to contain prolactin. The authors report the immunohistochemical localization of prolactin and 24K protein in late secretory endometrium using monoclonal antisera and the dinitrophenyl hapten sandwich-staining technique. The appearance of these proteins in decidualized stromal cells of late secretory endometrium may provide a more specific indicator of endometrial development and differentiation, if their late appearance or absence can be correlated with pregnancy wastage.

Original languageEnglish
Pages (from-to)643-648
Number of pages6
JournalFertility and Sterility
Issue number5
Publication statusPublished - Jan 1 1986

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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