Immunoreactive p53 and metallothionein expression in duct carcinoma in situ of the breast. No correlation

A. G. Douglas-Jones, H. Navabi, J. M. Morgan, B. Jasani

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Immunocytochemically detectable MT and p53 have been found more commonly in comedo DCIS of the breast with high-grade cytology. The aim of this study is to confirm these findings and to investigate the relationship between MT and p53 in a single large series of cases of DCIS of the breast. To this end, 127 cases of DCIS were classified histologically according to architecture, cytonuclear differentiation (grade), presence and extent of intraduct necrosis, and using the Van Nuys system. Sections were immunostained for p53 and MT (E9) using established techniques, and the extent and intensity of staining were assessed semi-quantitively. The results confirmed that there was generally more MT and p53 positivity in poorly differentiated (grade 3) DCIS with extensive necrosis and that MT expression was greater in grade 2 lesions than p53 expression. However, overall there was no statistically significant correlation between p53 and MT staining. The results indicate that MT and p53 overexpression may arise from independent mechanisms in early breast neoplasia.

Original languageEnglish
Pages (from-to)373-379
Number of pages7
JournalVirchows Archiv
Volume430
Issue number5
DOIs
Publication statusPublished - May 24 1997

Keywords

  • DCIS
  • Duct carcinoma of breast
  • Immunohistochemistry
  • Metallothionein
  • p53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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