Immunosorbents based on uncoated synthetic charcoals

Preparation, properties, applications

S. V. Mikhalovsky, V. V. Strelko, T. A. Alekseyeva, S. V. Komissarenko

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

By means of water-soluble carbodiimide coupling technique various bioligands were covalently attached to the surface of uncoated synthetic active carbons and a number of sorbents with certain biological functions were thus designed. Carbonaceous sorbents with immobilized ligands demonstrate increased affinity towards specific sorbates compared to that of starting matrix. As soon as SCN and SCS synthetic carbons are used uncoated they can be highly loaded with protein molecules - up to 80 mg serum albumin, 6-10 mg IgG rabbit etc. per gram of sorbent. Carbonaceous immunosorbents retain biocompatibility and substantial non-specific adsorptive capacity of initial hemosorbents. A conclusion is drawn that uncoated synthetic charcoals can serve a basis for design of selective hemosorbents intended for solving complicated problems of immunocorrection.

Original languageEnglish
Pages (from-to)671-681
Number of pages11
JournalBiomaterials, Artificial Cells, and Artificial Organs
Volume18
Issue number5
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Immunosorbents
Charcoal
Sorbents
Carbon
Carbodiimides
Serum Albumin
Immunoglobulin G
Rabbits
Ligands
Biocompatibility
Water
Proteins
Molecules

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mikhalovsky, S. V., Strelko, V. V., Alekseyeva, T. A., & Komissarenko, S. V. (1990). Immunosorbents based on uncoated synthetic charcoals: Preparation, properties, applications. Biomaterials, Artificial Cells, and Artificial Organs, 18(5), 671-681.

Immunosorbents based on uncoated synthetic charcoals : Preparation, properties, applications. / Mikhalovsky, S. V.; Strelko, V. V.; Alekseyeva, T. A.; Komissarenko, S. V.

In: Biomaterials, Artificial Cells, and Artificial Organs, Vol. 18, No. 5, 1990, p. 671-681.

Research output: Contribution to journalArticle

Mikhalovsky, SV, Strelko, VV, Alekseyeva, TA & Komissarenko, SV 1990, 'Immunosorbents based on uncoated synthetic charcoals: Preparation, properties, applications', Biomaterials, Artificial Cells, and Artificial Organs, vol. 18, no. 5, pp. 671-681.
Mikhalovsky, S. V. ; Strelko, V. V. ; Alekseyeva, T. A. ; Komissarenko, S. V. / Immunosorbents based on uncoated synthetic charcoals : Preparation, properties, applications. In: Biomaterials, Artificial Cells, and Artificial Organs. 1990 ; Vol. 18, No. 5. pp. 671-681.
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