TY - JOUR
T1 - Immunosorbents based os uncoated synthetic charcoals
T2 - Preparation, properties, applications
AU - Mikhalovsky, S. v.
AU - Strelko, V. V.
AU - Alekseyeva, T. A.
AU - Komissareuko, S. V.
PY - 1990/1
Y1 - 1990/1
N2 - By means of water-soluble carbodiimide coupling technique various bioligands were covalently attached to the surface of uncoated synthetic active carbons and a number of sorbents with certain biological functions were thus designed. Carbonaceous sorbents with immobilized ligands demonstrate increased affinity towards specific sorbates compared to that of starting matrix. As soon as SCN and SCS synthetic carbons are used uncoated they can be highly loaded with protein molecules - up to 80 mg serum albumin, 6-10 mg IgG rabbit etc. per gram of sorbeut. Carbonaceous immunosorbents retain biocompatibility and substantial non-specific adsorptive capacity of initial hemosorbents. A conclusion is drawn that uncoated synthetic charcoals can serve a basis for design of selective hemosorbents intended for solving complicated problems of immunocorrection.
AB - By means of water-soluble carbodiimide coupling technique various bioligands were covalently attached to the surface of uncoated synthetic active carbons and a number of sorbents with certain biological functions were thus designed. Carbonaceous sorbents with immobilized ligands demonstrate increased affinity towards specific sorbates compared to that of starting matrix. As soon as SCN and SCS synthetic carbons are used uncoated they can be highly loaded with protein molecules - up to 80 mg serum albumin, 6-10 mg IgG rabbit etc. per gram of sorbeut. Carbonaceous immunosorbents retain biocompatibility and substantial non-specific adsorptive capacity of initial hemosorbents. A conclusion is drawn that uncoated synthetic charcoals can serve a basis for design of selective hemosorbents intended for solving complicated problems of immunocorrection.
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U2 - 10.3109/10731199009117336
DO - 10.3109/10731199009117336
M3 - Article
C2 - 2099223
AN - SCOPUS:0025671961
VL - 18
SP - 671
EP - 681
JO - Artificial Cells, Nanomedicine and Biotechnology
JF - Artificial Cells, Nanomedicine and Biotechnology
SN - 2169-1401
IS - 5
ER -