Immunovirological outcome and HIV-1 DNA decay in a small cohort of HIV-1-infected patients deintensificated from Abacavir/Lamivudine/Dolutegravir to Lamivudine plus Dolutegravir

Massimiliano Lanzafame, Stefano Nicole, Sebastiano Rizzardo, Daniela Piacentini, Sheila Chiesi, Emanuela Lattuada, Erica Diani, Maria Carelli, Sandro Vento, Davide Gibellini

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Combination abacavir/lamivudine/dolutegravir (ABC/3TC/DTG) is approved as a first-line treatment for antiretroviral naïve patients. This report investigated the immunovirological outcome and total HIV-1 DNA decay in a small cohort of naïve HIV-1-positive patients treated with this regimen. In the presence of viral suppression and increased lymphocyte T CD4+ cells, the quantitative analysis of total HIV-1 DNA content revealed a significant decay after 12 months of treatment. Subsequently, we deintensificated the treatment of these patients from (ABC/3TC/DTG) to lamivudine plus dolutegravir (3TC/DTG) after 12 months of virological suppression, as a strategy of “induction-maintenance” therapy. The analysis of HIV-1 RNA viral load, total HIV-1 DNA, CD4+ T lymphocyte count and CD8+ HLA-DR+ T lymphocyte percentage after a mean 3.5 months of therapy deintensification showed no significant difference with respect to data detected after 12 months of ABC/3TC/DTG treatment in the presence of continuous viral suppression. These results indicate that the deintensification of highly active antiretroviral therapy (HAART) from ABC/3TC/DTG to 3TC/DTG effectively controls HIV-1 replication and in the early period does not induce any significant variations of total HIV-1 DNA. This suggests that HAART deintensification might be proposed as a therapeutic evolution in the treatment of HIV-1 infection.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalNew Microbiologica
Volume41
Issue number4
Publication statusPublished - Oct 2018

Keywords

  • Abacavir/lamivudine/dolutegravir
  • Deintensification
  • HAART
  • HIV DNA decay

ASJC Scopus subject areas

  • Microbiology (medical)

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