TY - JOUR
T1 - Implication of human herpesviruses in oncogenesis through immune evasion and supression
AU - Alibek, Kenneth
AU - Baiken, Yeldar
AU - Kakpenova, Ainur
AU - Mussabekova, Assel
AU - Zhussupbekova, Samal
AU - Akan, Madina
AU - Sultankulov, Bolat
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/1/20
Y1 - 2014/1/20
N2 - All human herpesviruses (HHVs) have been implicated in immune system evasion and suppression. Moreover, two HHV family members, i.e. EBV and KSHV, are recognised as oncogenic viruses. Our literature review summarises additional examples of possible oncogenic mechanisms that have been attributed to other HHVs. In general, HHVs affect almost every cancer-implicated branch of the immune system, namely tumour-promoting inflammation, immune evasion, and immunosuppression. Some HHVs accomplish these effects by inhibiting apoptotic pathways and by promoting proliferation. Mechanisms related to immunosupression and low grade chronic inflammation could eventually result in the initiation and progression of cancer. In this article we open a discussion on the members of Herpesviridae, their immune evasion and suppression mechanisms, and their possible role in cancer development. We conclude that discerning the mechanisms of interplay between HHV, immune system, and cancer is essential for the development of novel preventative and therapeutic approaches for cancer treatment and prophylaxis.
AB - All human herpesviruses (HHVs) have been implicated in immune system evasion and suppression. Moreover, two HHV family members, i.e. EBV and KSHV, are recognised as oncogenic viruses. Our literature review summarises additional examples of possible oncogenic mechanisms that have been attributed to other HHVs. In general, HHVs affect almost every cancer-implicated branch of the immune system, namely tumour-promoting inflammation, immune evasion, and immunosuppression. Some HHVs accomplish these effects by inhibiting apoptotic pathways and by promoting proliferation. Mechanisms related to immunosupression and low grade chronic inflammation could eventually result in the initiation and progression of cancer. In this article we open a discussion on the members of Herpesviridae, their immune evasion and suppression mechanisms, and their possible role in cancer development. We conclude that discerning the mechanisms of interplay between HHV, immune system, and cancer is essential for the development of novel preventative and therapeutic approaches for cancer treatment and prophylaxis.
KW - Antigen presentation
KW - Cancer
KW - Cytokine
KW - Herpesviruses
KW - Immune system
KW - Natural killer cells
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U2 - 10.1186/1750-9378-9-3
DO - 10.1186/1750-9378-9-3
M3 - Review article
AN - SCOPUS:84892465429
VL - 9
JO - Infectious Agents and Cancer
JF - Infectious Agents and Cancer
SN - 1750-9378
IS - 1
M1 - 3
ER -