Importance of basophils in eosinophilic asthma: The murine counterpart

D. Poddighe, C. B. Mathias, I. Brambilla, G. L. Marseglia, H. C. Oettgen

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Several experimental studies in mice showed that basophils participate in the initiation of Th2 adaptive immune response, in addition to the effector phase. However, the role of basophils in allergic airway inflammation is less clear. The aim of this experiment was to assess the importance of basophils in recruiting inflammatory cells and, in particular, eosinophils in a murine model of asthma induced by Aspergillus fumigatus allergens. Additionally, bronchial reactivity was evaluated. Basophil depletion resulted in a reduction of inflammatory cells in the airways and eosinophil recruitment was significantly impaired. Also bronchial reactivity seemed to be impaired in basophil-depleted mice, but the result was not statistically significant. According to these preliminary data, basophils seem to influence the local eosinophilic response of allergic asthma.

Original languageEnglish
Pages (from-to)35-339
Number of pages305
JournalJournal of Biological Regulators and Homeostatic Agents
Volume32
Issue number2
Publication statusPublished - Mar 1 2018

Keywords

  • Aspergillus fumigatus
  • Asthma
  • Basophils
  • Bronchial reactivity
  • Eosinophils
  • Mouse

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Physiology
  • Immunology
  • Oncology
  • Endocrinology
  • Physiology (medical)
  • Cancer Research

Fingerprint Dive into the research topics of 'Importance of basophils in eosinophilic asthma: The murine counterpart'. Together they form a unique fingerprint.

Cite this