TY - JOUR
T1 - In silico magnetic nanocontainers navigation in blood vessels
T2 - A feedback control approach
AU - Do, Ton Duc
AU - Noh, Yeongil
AU - Kim, Myeong Ok
AU - Yoon, Jungwon
N1 - Funding Information:
This work was supported by the Pioneer Research Center Program through the National Research Foundation of Korea, Ministry of Science, ICT and Future Planning under Grant 2012-0009524, and in part by NRF under Grant 2012R1A2A2A01047344 and 2014R1A2A1A11053989. Myeong Ok Kim contributed equally to this work as corresponding author.
PY - 2016/6
Y1 - 2016/6
N2 - Magnetic nanoparticles (MNPs) are recently used in a drug delivery system to pass the blood brain barrier. However, because the magnetic force acting on particles is proportional to their volumes, as the size of particles is small, the large magnetic field is required to produce enough magnetic force for overcoming the hydrodynamic drag force as well as other forces in blood vessels. Other difficulties for controlling MNPs are the complicated behavior of hydrodynamic drag force and uncertain factors in their dynamics. Therefore, open-loop control methods cannot guarantee guiding every MNP to the correct location. Considering these challenges, this paper introduces a feedback control approach for magnetic nanoparticles (MNPs) in blood vessels. To the best of our knowledge, this is the first time feedback controller that is designed for MNPs without aggregation. Simulation studies in MATLAB and real-time verifications on a physical model in COMSOL-MATLAB interface are performed to prove the feasibility. It shown that the proposed control scheme can accurately and effectively navigate the MNP to the correct path with feasible hardware supports
AB - Magnetic nanoparticles (MNPs) are recently used in a drug delivery system to pass the blood brain barrier. However, because the magnetic force acting on particles is proportional to their volumes, as the size of particles is small, the large magnetic field is required to produce enough magnetic force for overcoming the hydrodynamic drag force as well as other forces in blood vessels. Other difficulties for controlling MNPs are the complicated behavior of hydrodynamic drag force and uncertain factors in their dynamics. Therefore, open-loop control methods cannot guarantee guiding every MNP to the correct location. Considering these challenges, this paper introduces a feedback control approach for magnetic nanoparticles (MNPs) in blood vessels. To the best of our knowledge, this is the first time feedback controller that is designed for MNPs without aggregation. Simulation studies in MATLAB and real-time verifications on a physical model in COMSOL-MATLAB interface are performed to prove the feasibility. It shown that the proposed control scheme can accurately and effectively navigate the MNP to the correct path with feasible hardware supports
KW - Blood vessel
KW - Feedback control
KW - Magnetic nanocontainers
KW - Simulations
KW - Targeted drug delivery system.
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U2 - 10.1166/jnn.2016.12118
DO - 10.1166/jnn.2016.12118
M3 - Article
C2 - 27427720
AN - SCOPUS:84974661302
VL - 16
SP - 6368
EP - 6373
JO - Journal of Nanoscience and Nanotechnology
JF - Journal of Nanoscience and Nanotechnology
SN - 1533-4880
IS - 6
ER -