In situ correlation of synthesis and storage of parathormone in parathyroid gland disease

C. H. Kendall, L. Potter, R. Brown, B. Jasani, J. H. Pringle, I. Lauder

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The distribution and expression of parathyroid hormone (PTH) were investigated in normal and abnormal parathyroid tissue. PTH was detected using a monoclonal antibody with specificity for the 44-68 region of the PTH molecule. Prominent reactivity for PTH was seen in normal parathyroid with a granular pattern of staining. Active parathyroid tissue (adenoma and hyperplasia) showed much less reactivity for PTH, although there was prominent reactivity in the normal tissue around adenomas. Comparison of expression of PTH with that of parathormone mRNA showed a reciprocal pattern in normal tissue and, to a less marked extent, in abnormal tissue. Parathyroid carcinoma in particular had coinciding areas of PTH and PTH mRNA expression. Oxyphil cells had little or no PTH expression, except in the associated 'colloid' in some cases. The findings indicate an inverse relationship between storage and cellular synthesis of PTH, this being more marked in physiological than in pathological conditions of the parathyroid.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalJournal of Pathology
Volume169
Issue number1
DOIs
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Parathyroid Diseases
Parathyroid Glands
Parathyroid Hormone
Parathyroid Neoplasms
Oxyphil Cells
Messenger RNA
Antibody Specificity
Colloids
Adenoma
Hyperplasia

Keywords

  • Immunocytochemistry
  • In situ hybridization
  • Messenger RNA
  • Parathormone

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kendall, C. H., Potter, L., Brown, R., Jasani, B., Pringle, J. H., & Lauder, I. (1993). In situ correlation of synthesis and storage of parathormone in parathyroid gland disease. Journal of Pathology, 169(1), 61-66. https://doi.org/10.1002/path.1711690110

In situ correlation of synthesis and storage of parathormone in parathyroid gland disease. / Kendall, C. H.; Potter, L.; Brown, R.; Jasani, B.; Pringle, J. H.; Lauder, I.

In: Journal of Pathology, Vol. 169, No. 1, 1993, p. 61-66.

Research output: Contribution to journalArticle

Kendall, CH, Potter, L, Brown, R, Jasani, B, Pringle, JH & Lauder, I 1993, 'In situ correlation of synthesis and storage of parathormone in parathyroid gland disease', Journal of Pathology, vol. 169, no. 1, pp. 61-66. https://doi.org/10.1002/path.1711690110
Kendall, C. H. ; Potter, L. ; Brown, R. ; Jasani, B. ; Pringle, J. H. ; Lauder, I. / In situ correlation of synthesis and storage of parathormone in parathyroid gland disease. In: Journal of Pathology. 1993 ; Vol. 169, No. 1. pp. 61-66.
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