In-situ, real-time monitoring of thermo-mechanical properties of biological tissues undergoing laser heating and ablation

Bayan Kurbanova, Shakhrizat Alisherov, Zhannat Ashikbayeva, Zhanerke Katrenova, Akbota Sametova, Abduzhappar Gaipov, Carlo Molardi, Wilfried Blanc, Daniele Tosi, Zhandos Utegulov

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, Brillouin light-scattering spectroscopy and optical backscattering reflectometry (OBR) using Mgx2013;silica-NP-doped distributed sensing fibers were employed for monitoring local GHz visco-elastic properties and surface temperature, respectively, during laser driven heating and ablation of chicken tissues. The spatial temperature distribution measured by OBR at various infrared laser heating powers and times was used to validate spatio-temporal local temperature variations modeled by the finite element method via solving Pennesx2019; bioheat conduction equation. The reduction of viscosity and stiffness in chicken skin during its laser heating was attributed to water loss, protein denaturation and change in lipid phase behavior. These findings open avenues for the simultaneous real-time hybrid optical sensing of both viscoelasticity and local temperature in biological tissues undergoing denaturation and gelation during thermal ablation in clinical settings.
Original languageEnglish
Pages (from-to)6198-6210
Number of pages13
JournalBiomed. Opt. Express
Volume15
Issue number11
DOIs
Publication statusPublished - Nov 1 2024

Keywords

  • Brillouin spectroscopy
  • High power lasers
  • Infrared lasers
  • Laser beams
  • Laser sources
  • Spatial resolution

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