In vitro effect of TP-1 (a calf thymic extract) on suppressor T-cell function of patients with autoimmune chronic active hepatitis

C. J. O'Brien, K. T. Nouri-Aria, J. E. Hegarty, S. Vento, A. L.W.F. Eddleston, Roger Williams

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Concanavalin A-activated T-lymphocyte suppression of IgG production was found to be significantly impaired in patients with untreated active autoimmune chronic hepatitis when compared to normals or patients with inactive disease. When the dose-response effect of TP-1, a calf thymic extract, on in vitro suppressor cell activity was assessed, lymphocytes from six out of eight patients with previously reduced suppressor cell function showed a significant improvement, while over a similar range the suppressor cell activity of most normal controls declined. These results support the possibility that defective immunoregulation in patients with autoimmune chronic active hepatitis may be related to a deficiency in thymic hormone levels.

Original languageEnglish
Pages (from-to)651-656
Number of pages6
JournalInternational Journal of Immunopharmacology
Volume10
Issue number6
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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