Abstract
The deployment of a vascular stent during angioplasty has greatly reduced the risks of restenosis. However, the presence of the device still induces a host response as well as a mechanical action on the blood vessel wall and an alteration of the haemodynamics. Platelet and inflammatory cells can adhere on the stent surface and be activated to produce biochemical signals able to stimulate an excessive proliferation of the smooth muscle cells with the consequent obstruction of the vessel lumen. For these reasons, the host response to two of the materials used in stent manufacture, stainless steel and diamond-like carbon, was investigated in vitro. The data showed that stainless steel induced a higher level of host response both in terms of platelet aggregation and macrophage activation. However, the spreading of inflammatory cells was more accentuated on diamond-like carbon. The inflammatory cells produced levels of platelet-derived growth factor, a key signal in smooth muscle cell proliferation, similar to stainless steel thus suggesting that carbon coatings may not be able to prevent restenosis.
| Original language | English |
|---|---|
| Pages (from-to) | 473-477 |
| Number of pages | 5 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
- Bioengineering
- Chemical Engineering(all)
Cite this
In vitro host response assessment of biomaterials for cardiovascular stent manufacture. / Santin, Matteo; Mikhalovska, Lyuba; Lloyd, Andrew W.; Mikhalovsky, Sergey; Sigfrid, Louise; Denyer, Stephen P.; Field, Susanna; Teer, Dennis.
In: Journal of Materials Science: Materials in Medicine, Vol. 15, No. 4, 04.2004, p. 473-477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro host response assessment of biomaterials for cardiovascular stent manufacture
AU - Santin, Matteo
AU - Mikhalovska, Lyuba
AU - Lloyd, Andrew W.
AU - Mikhalovsky, Sergey
AU - Sigfrid, Louise
AU - Denyer, Stephen P.
AU - Field, Susanna
AU - Teer, Dennis
PY - 2004/4
Y1 - 2004/4
N2 - The deployment of a vascular stent during angioplasty has greatly reduced the risks of restenosis. However, the presence of the device still induces a host response as well as a mechanical action on the blood vessel wall and an alteration of the haemodynamics. Platelet and inflammatory cells can adhere on the stent surface and be activated to produce biochemical signals able to stimulate an excessive proliferation of the smooth muscle cells with the consequent obstruction of the vessel lumen. For these reasons, the host response to two of the materials used in stent manufacture, stainless steel and diamond-like carbon, was investigated in vitro. The data showed that stainless steel induced a higher level of host response both in terms of platelet aggregation and macrophage activation. However, the spreading of inflammatory cells was more accentuated on diamond-like carbon. The inflammatory cells produced levels of platelet-derived growth factor, a key signal in smooth muscle cell proliferation, similar to stainless steel thus suggesting that carbon coatings may not be able to prevent restenosis.
AB - The deployment of a vascular stent during angioplasty has greatly reduced the risks of restenosis. However, the presence of the device still induces a host response as well as a mechanical action on the blood vessel wall and an alteration of the haemodynamics. Platelet and inflammatory cells can adhere on the stent surface and be activated to produce biochemical signals able to stimulate an excessive proliferation of the smooth muscle cells with the consequent obstruction of the vessel lumen. For these reasons, the host response to two of the materials used in stent manufacture, stainless steel and diamond-like carbon, was investigated in vitro. The data showed that stainless steel induced a higher level of host response both in terms of platelet aggregation and macrophage activation. However, the spreading of inflammatory cells was more accentuated on diamond-like carbon. The inflammatory cells produced levels of platelet-derived growth factor, a key signal in smooth muscle cell proliferation, similar to stainless steel thus suggesting that carbon coatings may not be able to prevent restenosis.
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U2 - 10.1023/B:JMSM.0000021123.51752.11
DO - 10.1023/B:JMSM.0000021123.51752.11
M3 - Article
VL - 15
SP - 473
EP - 477
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 4
ER -