In vitro host response assessment of biomaterials for cardiovascular stent manufacture

Matteo Santin, Lyuba Mikhalovska, Andrew W. Lloyd, Sergey Mikhalovsky, Louise Sigfrid, Stephen P. Denyer, Susanna Field, Dennis Teer

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The deployment of a vascular stent during angioplasty has greatly reduced the risks of restenosis. However, the presence of the device still induces a host response as well as a mechanical action on the blood vessel wall and an alteration of the haemodynamics. Platelet and inflammatory cells can adhere on the stent surface and be activated to produce biochemical signals able to stimulate an excessive proliferation of the smooth muscle cells with the consequent obstruction of the vessel lumen. For these reasons, the host response to two of the materials used in stent manufacture, stainless steel and diamond-like carbon, was investigated in vitro. The data showed that stainless steel induced a higher level of host response both in terms of platelet aggregation and macrophage activation. However, the spreading of inflammatory cells was more accentuated on diamond-like carbon. The inflammatory cells produced levels of platelet-derived growth factor, a key signal in smooth muscle cell proliferation, similar to stainless steel thus suggesting that carbon coatings may not be able to prevent restenosis.

Original languageEnglish
Pages (from-to)473-477
Number of pages5
JournalJournal of Materials Science: Materials in Medicine
Volume15
Issue number4
DOIs
Publication statusPublished - Apr 2004
Externally publishedYes

Fingerprint

Stents
Stainless Steel
Biocompatible Materials
Platelets
Biomaterials
Diamond
Carbon
Stainless steel
Smooth Muscle Myocytes
Blood Vessels
Muscle
Diamonds
Macrophage Activation
Macrophages
Platelet-Derived Growth Factor
Platelet Activation
Blood vessels
Cell proliferation
Hemodynamics
Platelet Aggregation

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Chemical Engineering(all)

Cite this

Santin, M., Mikhalovska, L., Lloyd, A. W., Mikhalovsky, S., Sigfrid, L., Denyer, S. P., ... Teer, D. (2004). In vitro host response assessment of biomaterials for cardiovascular stent manufacture. Journal of Materials Science: Materials in Medicine, 15(4), 473-477. https://doi.org/10.1023/B:JMSM.0000021123.51752.11

In vitro host response assessment of biomaterials for cardiovascular stent manufacture. / Santin, Matteo; Mikhalovska, Lyuba; Lloyd, Andrew W.; Mikhalovsky, Sergey; Sigfrid, Louise; Denyer, Stephen P.; Field, Susanna; Teer, Dennis.

In: Journal of Materials Science: Materials in Medicine, Vol. 15, No. 4, 04.2004, p. 473-477.

Research output: Contribution to journalArticle

Santin, M, Mikhalovska, L, Lloyd, AW, Mikhalovsky, S, Sigfrid, L, Denyer, SP, Field, S & Teer, D 2004, 'In vitro host response assessment of biomaterials for cardiovascular stent manufacture', Journal of Materials Science: Materials in Medicine, vol. 15, no. 4, pp. 473-477. https://doi.org/10.1023/B:JMSM.0000021123.51752.11
Santin, Matteo ; Mikhalovska, Lyuba ; Lloyd, Andrew W. ; Mikhalovsky, Sergey ; Sigfrid, Louise ; Denyer, Stephen P. ; Field, Susanna ; Teer, Dennis. / In vitro host response assessment of biomaterials for cardiovascular stent manufacture. In: Journal of Materials Science: Materials in Medicine. 2004 ; Vol. 15, No. 4. pp. 473-477.
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