Incidence and mortality rates of strokes in Kazakhstan in 2014-2019

Gulnur Zhakhina; Bakhytbek Zhalmagambetov; Arnur Gusmanov; Yesbolat Sakko; Sauran Yerdessov; Elzar Matmusaeva; Aliya Imanova; Byron Crape; Antonio Sarria-Santamera; Abduzhappar Gaipov

doi:10.1038/s41598-022-20302-8

Incidence and mortality rates of strokes in Kazakhstan in 2014-2019

Gulnur Zhakhina, Bakhytbek Zhalmagambetov, Arnur Gusmanov, Yesbolat Sakko, Sauran Yerdessov, Elzar Matmusaeva, Aliya Imanova, Byron Crape, Antonio Sarria-Santamera, Abduzhappar Gaipov

Department of Medicine

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

There is a lack of information on the epidemiology of acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in developing countries. This research presents incidence and mortality rates of stroke patients based on hospital admission and discharge status in one of the Central Asian countries by analysis of large-scale healthcare data. The registry data of 177,947 patients admitted to the hospital with the diagnosis of stroke between 2014 and 2019 were extracted from the National Electronic Health System of Kazakhstan. We provide descriptive statistics and analyze the association of socio-demographic and medical characteristics such as comorbidities and surgical treatments. Among all stroke patients, the incidence rate based on hospital admission of AIS was significantly higher compared to SAH and ICH patients. In 5 year follow-up period, AIS patients had a better outcome than SAH and ICH patients (64.7, 63.1 and 57.3% respectively). The hazard ratio (HR) after the trepanation and decompression surgery was 2.3 and 1.48 for AIS and SAH patients; however, it was protective for ICH (HR = 0.87). The investigation evaluated an increase in the all-cause mortality rates based on the discharge status of stroke patients, while the incidence rate decreased over time.

Original language	English
Pages (from-to)	16041
Journal	Scientific Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-20302-8
Publication status	Published - Sept 26 2022

Funding

This study was supported by grants from the Nazarbayev University Faculty Development Research Grant Program FDCRGP 2020–2022 (Funder Project Reference: 240919FD3913, title: Aggregation and utilization of the large-scale administrative health data in Kazakhstan for population health research and surveillance). The funder had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. A.G. is a PI of the project. We thank all staff from the Republican Center of Electronic Healthcare for providing data and consultancy. Portions of this manuscript were presented at the 8th European Stroke Organization Conference (ESOC), Lyon, France, 4-6 May 2022.

Keywords

Cerebral Hemorrhage/diagnosis
Humans
Incidence
Ischemic Stroke
Kazakhstan/epidemiology
Stroke/diagnosis
Subarachnoid Hemorrhage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-022-20302-8

Cite this

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abstract = "There is a lack of information on the epidemiology of acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in developing countries. This research presents incidence and mortality rates of stroke patients based on hospital admission and discharge status in one of the Central Asian countries by analysis of large-scale healthcare data. The registry data of 177,947 patients admitted to the hospital with the diagnosis of stroke between 2014 and 2019 were extracted from the National Electronic Health System of Kazakhstan. We provide descriptive statistics and analyze the association of socio-demographic and medical characteristics such as comorbidities and surgical treatments. Among all stroke patients, the incidence rate based on hospital admission of AIS was significantly higher compared to SAH and ICH patients. In 5 year follow-up period, AIS patients had a better outcome than SAH and ICH patients (64.7, 63.1 and 57.3\% respectively). The hazard ratio (HR) after the trepanation and decompression surgery was 2.3 and 1.48 for AIS and SAH patients; however, it was protective for ICH (HR = 0.87). The investigation evaluated an increase in the all-cause mortality rates based on the discharge status of stroke patients, while the incidence rate decreased over time.",

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AU - Zhakhina, Gulnur

AU - Zhalmagambetov, Bakhytbek

AU - Gusmanov, Arnur

AU - Sakko, Yesbolat

AU - Yerdessov, Sauran

AU - Matmusaeva, Elzar

AU - Imanova, Aliya

AU - Crape, Byron

AU - Sarria-Santamera, Antonio

AU - Gaipov, Abduzhappar

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AB - There is a lack of information on the epidemiology of acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in developing countries. This research presents incidence and mortality rates of stroke patients based on hospital admission and discharge status in one of the Central Asian countries by analysis of large-scale healthcare data. The registry data of 177,947 patients admitted to the hospital with the diagnosis of stroke between 2014 and 2019 were extracted from the National Electronic Health System of Kazakhstan. We provide descriptive statistics and analyze the association of socio-demographic and medical characteristics such as comorbidities and surgical treatments. Among all stroke patients, the incidence rate based on hospital admission of AIS was significantly higher compared to SAH and ICH patients. In 5 year follow-up period, AIS patients had a better outcome than SAH and ICH patients (64.7, 63.1 and 57.3% respectively). The hazard ratio (HR) after the trepanation and decompression surgery was 2.3 and 1.48 for AIS and SAH patients; however, it was protective for ICH (HR = 0.87). The investigation evaluated an increase in the all-cause mortality rates based on the discharge status of stroke patients, while the incidence rate decreased over time.

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KW - Humans

KW - Incidence

KW - Ischemic Stroke

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KW - Stroke/diagnosis

KW - Subarachnoid Hemorrhage

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ER -

Incidence and mortality rates of strokes in Kazakhstan in 2014-2019

Abstract

Funding

Keywords

UN SDGs

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