Influence of waveform on cell viability during ultrasound exposure

Timur Saliev, Loreto B. Feril, Donald A. McLean, Katsuro Tachibana, Paul A. Campbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We examined the role of ultrasound standing waves, and their travelling wave counterparts, on cell viability in an in-vitro insonation apparatus. Furthermore, the effect of distinct waveforms (sine and top-hat) was also explored, together with the role of microbubble presence. Measurements of cell viability in standing wave scenarios demonstrated a relatively higher rate of lysis (63.13 ± 10.89% remaining viable) compared with the travelling wave data, where 96.22 ± 4.0% remained viable. Significant differences were also seen as a function of waveform, where insonations employing top-hat wave shapes resulted in an average end stage viability of 30.31 ± 5.71 % compared with 61.94 ± 14.28 % in the sinusoidal counterparts.

Original languageEnglish
Title of host publication10th International Symposium on Therapeutic Ultrasound, ISTU 2010
Pages367-370
Number of pages4
DOIs
Publication statusPublished - Oct 13 2011
Externally publishedYes
Event10th International Symposium on Therapeutic Ultrasound, ISTU 2010 - Tokyo, Japan
Duration: Jun 9 2010Jun 12 2010

Publication series

NameAIP Conference Proceedings
Volume1359
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other10th International Symposium on Therapeutic Ultrasound, ISTU 2010
CountryJapan
CityTokyo
Period6/9/106/12/10

Keywords

  • Cell viability
  • Standing waves
  • Ultrasound therapy
  • Wave-form dependence

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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