Inhibition of α-Amylase and α-Glucosidase by New β-Aminopropionamidoxime Derivatives

L. A. Kayukova, A. B. Uzakova, G. P. Baitursynova, G. T. Dyusembaeva, Z. T. Shul’gau, Alexander Gulyayev, Sh D. Sergazy

    Research output: Contribution to journalArticle

    Abstract

    New antidiabetic agents are being sought because of the global problem with diabetes. Amidoxime derivatives are known to have antidiabetic activity. β-Aminopropionamidoxime bases and pharmacologically acceptable salts of O-aroyl-β-(morpholin-1-yl)propionamidoximes and 5-substituted phenyl-3-β-(piperidin-1-yl and morpholin-1-yl)ethyl-1,2,4-oxadiazoles were screened in vitro for antidiabetic activity manifested as inhibition of α-amylase and α-glucosidase. Compounds with pronounced antidiabetic properties were identified. The series of 3,5-disubstituted 1,2,4-oxadiazoles were more active than the series of O-aroyl-β-aminopropionamidoximes. The results could be used for further in vivo screening of the antidiabetic properties of the most promising compounds with a preliminary assessment of their mean toxic doses in animals.

    Original languageEnglish
    Pages (from-to)129-133
    Number of pages5
    JournalPharmaceutical Chemistry Journal
    Volume53
    Issue number2
    DOIs
    Publication statusPublished - May 5 2019

    Fingerprint

    Glucosidases
    Amylases
    Hypoglycemic Agents
    Oxadiazoles
    Poisons
    Salts

    Keywords

    • bases and pharmacologically acceptable salts of O-aroyl-β-(morpholin-1-yl)propionamidoximes and 5-substituted phenyl-3-β-(piperidin-1-yl and morpholin-1-yl)ethyl-1,2,4-oxadiazoles
    • in vitro antidiabetic screening for inhibition of α-amylase and α-glucosidase

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

    Cite this

    Kayukova, L. A., Uzakova, A. B., Baitursynova, G. P., Dyusembaeva, G. T., Shul’gau, Z. T., Gulyayev, A., & Sergazy, S. D. (2019). Inhibition of α-Amylase and α-Glucosidase by New β-Aminopropionamidoxime Derivatives. Pharmaceutical Chemistry Journal, 53(2), 129-133. https://doi.org/10.1007/s11094-019-01966-5

    Inhibition of α-Amylase and α-Glucosidase by New β-Aminopropionamidoxime Derivatives. / Kayukova, L. A.; Uzakova, A. B.; Baitursynova, G. P.; Dyusembaeva, G. T.; Shul’gau, Z. T.; Gulyayev, Alexander; Sergazy, Sh D.

    In: Pharmaceutical Chemistry Journal, Vol. 53, No. 2, 05.05.2019, p. 129-133.

    Research output: Contribution to journalArticle

    Kayukova, LA, Uzakova, AB, Baitursynova, GP, Dyusembaeva, GT, Shul’gau, ZT, Gulyayev, A & Sergazy, SD 2019, 'Inhibition of α-Amylase and α-Glucosidase by New β-Aminopropionamidoxime Derivatives', Pharmaceutical Chemistry Journal, vol. 53, no. 2, pp. 129-133. https://doi.org/10.1007/s11094-019-01966-5
    Kayukova, L. A. ; Uzakova, A. B. ; Baitursynova, G. P. ; Dyusembaeva, G. T. ; Shul’gau, Z. T. ; Gulyayev, Alexander ; Sergazy, Sh D. / Inhibition of α-Amylase and α-Glucosidase by New β-Aminopropionamidoxime Derivatives. In: Pharmaceutical Chemistry Journal. 2019 ; Vol. 53, No. 2. pp. 129-133.
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