Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose

Yingqiu Xie, Olena Filchakova, Qing Yang, Yerkebulan Yesbolatov, Darkhan Tursynkhan, Aishabibi Kassymbek, Mohamed Bouhrara, Kunjie Wang, Mannix Balanay, Haiyan Fan

Research output: Contribution to journalArticle

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Abstract

Water-soluble fluorescent carbon dots (C-dots) were synthesized through hydrothermal process using date pits pre-treated with phosphoric acid as a carbon source. Transmission electron microscopy showed that the C-dots have an average particle size of 1.1 ± 0.3 nm with a very narrow size distribution. The aqueous solution or the phosphate buffer solution (PBS) of as prepared C-dots exhibits strong fluorescence when excited at 338 nm. The PBS solution of the as prepared C-dots can inhibit growth by as much as 61% as well as migration of human lung cancer (A549), breast cancer (MCF-7) and prostate cancer (PC3) cells at the concentration of 0.1 mg/ml. However, only 14% inhibition was observed for kidney (HEK293) cells at the same dose. In addition, the application of C-dots was found to lead to the increase in thickness of the actin stress fiber, which may inhibit cell migration dynamics. Thus, nanomaterials such as date pits-derived C-dots may be applied as anti-cancer agents.

Original languageEnglish
Pages (from-to)4079-4083
Number of pages5
JournalChemistrySelect
Volume2
Issue number14
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Cell proliferation
Carbon
Buffers
Phosphates
Nanostructured materials
Actins
Fluorescence
Particle size
Transmission electron microscopy
Water
Fibers

Keywords

  • Bioimaging
  • Cancer cells
  • Cell inhibition
  • Cell migration
  • Natural carbon dots

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose. / Xie, Yingqiu; Filchakova, Olena; Yang, Qing; Yesbolatov, Yerkebulan; Tursynkhan, Darkhan; Kassymbek, Aishabibi; Bouhrara, Mohamed; Wang, Kunjie; Balanay, Mannix; Fan, Haiyan.

In: ChemistrySelect, Vol. 2, No. 14, 01.01.2017, p. 4079-4083.

Research output: Contribution to journalArticle

Xie, Y, Filchakova, O, Yang, Q, Yesbolatov, Y, Tursynkhan, D, Kassymbek, A, Bouhrara, M, Wang, K, Balanay, M & Fan, H 2017, 'Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose', ChemistrySelect, vol. 2, no. 14, pp. 4079-4083. https://doi.org/10.1002/slct.201700575
Xie Y, Filchakova O, Yang Q, Yesbolatov Y, Tursynkhan D, Kassymbek A et al. Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose. ChemistrySelect. 2017 Jan 1;2(14):4079-4083. https://doi.org/10.1002/slct.201700575
Xie, Yingqiu ; Filchakova, Olena ; Yang, Qing ; Yesbolatov, Yerkebulan ; Tursynkhan, Darkhan ; Kassymbek, Aishabibi ; Bouhrara, Mohamed ; Wang, Kunjie ; Balanay, Mannix ; Fan, Haiyan. / Inhibition of Cancer Cell Proliferation by Carbon Dots Derived from Date Pits at Low-Dose. In: ChemistrySelect. 2017 ; Vol. 2, No. 14. pp. 4079-4083.
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