Inorganic coatings for cardiovascular stents: In vitro and in vivo studies

Lyuba Mikhalovska, Nataliya Chorna, Oleg Lazarenko, Peter Haworth, Arnaud Sudre, Sergey Mikhalovsky

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The in-vitro and in-vivo biocompatibility of two oxides (TiO and ZrO) and diamond-like carbon (D) coated stents has been assessed and compared with uncoated stainless steel (St) stents. In vitro studies demonstrated that both fibrinogen adsorption and platelet adhesion were significantly higher on D coating compared to those on oxide coatings and uncoated stainless steel. In addition TiO and ZrO coatings showed evidence of a minor inflammatory response and more complete endothelialization of the aorta than that seen around D coated and uncoated St stents. The resulting neointimal growth in the aorta with TiO, ZrO, and D coated and uncoated St stents, measured 8 weeks after stenting (the ratio of the neointima in the stented artery to the non-stented artery) was 1.03 + 0.28, 0.85 + 0.36, 1.78 + 1.26, and 1.15 + 0.56, accordingly. From the data obtained it could be concluded that the increased neointima measured around D-coated stents, may be due to both, the inferior haemocompatibility of the diamond-like carbon coating and mechanical instability of D coating observed in an in vivo environment.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume96 B
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • carbon
  • hemocompatability
  • restenosis
  • titanium oxide
  • zirconia

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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