Integration of fiber optic sensors in organ-on-a-chip devices towards label-free cell viability assays

Sanzhar Shakarim, Daniele Tosi, Gulsim Kulsharova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this paper, we report a microfluidic polymer organ-on-a-chip device integrated with a fiber optic sensor towards online monitoring of cell viability on-chip. As preliminary model applications, absorbance-based measurements of various concentrations of sucrose solution and of AlluraRed dye in the chip were carried out. Absorbance peaks were correlated to concentrations of the solutions and analyzed. Accurate sensing of analytes in a continuous flow through the device was achieved. Fiber optic sensor integrated microfluidic chip can be used as a label-free assay for cell viability measurements and other applications based on change of absorbance and luminescence values of the cellular microenvironment in organ-on-a-chip devices.

Original languageEnglish
Title of host publication2022 IEEE Sensors Applications Symposium, SAS 2022 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781665409810
DOIs
Publication statusPublished - 2022
Event17th IEEE Sensors Applications Symposium, SAS 2022 - Sundsvall, Sweden
Duration: Aug 1 2022Aug 3 2022

Publication series

Name2022 IEEE Sensors Applications Symposium, SAS 2022 - Proceedings

Conference

Conference17th IEEE Sensors Applications Symposium, SAS 2022
Country/TerritorySweden
CitySundsvall
Period8/1/228/3/22

Keywords

  • absorbance
  • bioassays
  • cell viability
  • fiber optic sensor
  • microfluidics
  • organ-on-a-chip

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Electrical and Electronic Engineering
  • Instrumentation

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